Output organization of intermediate cerebellum of the monkey.
Output organization of intermediate cerebellum of the monkey.
复制标题
猴子中间小脑的输出组织。
DOI：
10.1152/jn.1993.69.1.57
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
Gibson,AR
中科院分区：
文献类型：
--
作者：
vanKan,PL;Houk,JC;Gibson,AR
1.本研究的目的是通过将单个神经元的放电与主动运动相关联来研究猴间核（NI）和外侧核（NL）邻近区域的运动组织。在自由运动期间以及需要围绕特定前肢关节运动的六种设备的操作期间对神经元进行了调查。该范例使我们能够检验单个细胞的放电与单个关节的运动相关的假设。 2. 研究了来自两只猴子的一百六十二个分离的核神经元。 83% 的人在身体某一部位（前肢、后肢、嘴/脸或眼睛）运动期间放电量大幅增加（前肢神经元平均为静息率的 3 倍）。 3.前间肌包含前部区域与后肢运动相关的神经元和后部区域与前肢运动相关的神经元。嘴/脸相关区域存在于背侧后部区域中并且与NL的背侧区域中的嘴/脸区域连续。后间肌（NIP）显示前肢和后肢神经元之间没有明显的分离：前肢神经元遍布整个细胞核，而后肢神经元则出现在内侧前三分之二处。 NIP 的外侧、后部和腹侧区域存在明显的眼球运动区域。该区域与 NL 区域接壤，该区域也包含与眼动相关的神经元。 4. 前肢间肌神经元在伸手和抓握过程中放电强烈；在定型到达期间记录了 41 个神经元的放电速率，平均调制深度为 149 imp/s。在设备跟踪过程中调制的 19 个神经元也在到达过程中进行了测试，并且在到达过程中调制的深度要大得多。 5. 使用设备跟踪测试了 59 个前肢神经元。无论锻炼哪个关节，二十七名（46%）都没有发出声音调制。其余 32 个神经元在至少一台设备上运动期间受到调制（平均调制深度 = 84 imp/s）。对不同设备使用过程中的放电进行比较，没有发现设备特定放电的有力证据。 6. 设备跟踪过程中的放电调制是阶段性的、先于运动的，并且对于少数细胞而言，显示出与运动的持续时间、幅度和速度一致的参数关系。 7. 尽管 NI 和 NL 内有清晰的体位图，但没有基于前肢区域内各个关节的主动运动的更精细的映射。放电调节取决于涉及整个肢体的运动。理解中间小脑功能的进展取决于确定引起一致和高度调节神经放电所需的变量。（摘要截断为 400 字）
1. The goal of this study was to investigate the motor organization of monkey nucleus interpositus (NI) and neighboring regions of the lateral nucleus (NL) by correlating discharge of single neurons with active movements. Neurons were surveyed during free-form movements as well as during operation of six devices that required movement about specific forelimb joints. The paradigm allowed us to test the hypothesis that discharge of individual cells relates to movements about individual joints. 2. One hundred sixty-two isolated nuclear neurons from two monkeys were studied. Eighty-three percent showed large increases in discharge (an average of 3 times resting rate for forelimb neurons) during movement of one body part, either forelimb, hindlimb, mouth/face, or eyes. 3. Anterior interpositus contains neurons related to hindlimb movement in anterior regions and neurons related to forelimb movement in posterior regions. A mouth/face-related area exists in the dorsal-posterior regions and is continuous with a mouth/face area in the dorsal regions of NL. Posterior interpositus (NIP) showed no clear separation between forelimb and hindlimb neurons: forelimb neurons were encountered throughout the nucleus, and hindlimb neurons were encountered in the medial-anterior two thirds. A distinct eye movement area exists in lateral, posterior, and ventral regions of NIP. This area borders regions of NL that also contain eye movement-related neurons. 4. Forelimb interpositus neurons discharged strongly during reach and grasp; discharge rates were recorded for 41 neurons during a stereotyped reach and the average depth of modulation was 149 imp/s. Nineteen neurons that modulated during device tracking were also tested during reaching, and the depth of modulation was much greater during reaching. 5. Fifty-nine forelimb neurons were tested with device tracking. Twenty-seven (46%) produced no audible modulation, regardless of the joint being exercised. The remaining 32 neurons modulated during movement on at least one device (mean depth of modulation = 84 imp/s). Comparison of discharge during use of different devices revealed no strong evidence for device-specific discharge. 6. Discharge modulations during device tracking were phasic, preceded movement, and, for a small number of cells, showed consistent parametric relations to duration, amplitude, and velocity of movement. 7. Despite a clear somatotopy within NI and NL, there is no finer mapping based on active movements about individual joints within forelimb regions. Discharge modulation depends on movements involving the whole limb. Progress in understanding the function of intermediate cerebellum depends on determining the variables required to elicit consistent and high modulation of neural discharge.(ABSTRACT TRUNCATED AT 400 WORDS)