Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath
Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath
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DOI：
10.1039/c1cc10343a
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Zenobi, Renato
中科院分区：
文献类型：
--
作者：
Gamez, Gerardo;Zhu, Liang;Zenobi, Renato
萃取电喷雾电离质谱仪被证明能够以非侵入性、无痛的方式进行实时的在体药物监测和药代动力学测量，如用于控制癫痫的药物丙戊酸的新型呼气生物标志物的质谱测量所证明的那样。
Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.