Thalamic relay of afferent responses to 1- to 12-Hz whisker stimulation in the rat
Thalamic relay of afferent responses to 1- to 12-Hz whisker stimulation in the rat
复制标题
DOI：
10.1152/jn.1998.80.2.1016
复制
发表时间：
1998-08-01
影响因子：
2.5
通讯作者：
Simons, DJ
中科院分区：
文献类型：
--
作者：
Hartings, JA;Simons, DJ
大鼠的体感觉皮质神经元可以被携带到至少12赫兹的脉冲须刺激频率下。最近的一项研究提出，这种夹带依赖于振荡的皮质丘脑反馈。根据该模型，丘脑中继神经元作为上升和下降信号的比较器，应根据外周刺激频率改变其反应幅度和潜伏期。然而，在这里，我们报告了丘脑中继神经元对1- 12赫兹脉冲晶须偏转的反应在这些频率上的幅度和延迟是恒定的。此外，它们的周期响应与初级传入神经元一样不变。这些结果支持了丘脑中继神经元主要由上行传入信号驱动，从而通过直接前馈机制将皮质神经元带入外周刺激的观点。
Somatosensory cortical neurons in the rat can be entrained to frequencies of pulsatile whisker stimulation up to at least 12 Hz. A recent study proposed that such entrainment depends on oscillatory corticothalamic feedback. According to this model, thalamic relay neurons function as comparators of ascending and descending signals and should vary their response magnitudes and latencies as a function of peripheral stimulation frequency. Here we report, however, that the responses of thalamic relay neurons to 1- to 12-Hz pulsatile whisker deflections are constant in magnitude and latency over these frequencies. In addition, their cycle-by-cycle responses are as invariant as those of primary afferent neurons. These results support the view that thalamic relay neurons are driven primarily by ascending afferent signals and thereby entrain cortical neurons to peripheral stimulation by means of a direct feed-forward mechanism.