The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
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DOI：
10.1016/j.bbr.2006.10.018
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发表时间：
2007-01-25
影响因子：
2.7
通讯作者：
Kelly, Aine M.
中科院分区：
文献类型：
--
作者：
O'Callaghan, Rachel M.;Ohle, Robert;Kelly, Aine M.
体力活动可能有改善认知功能的潜力。在这里，我们表明，强制跑步机运行结果在海马可塑性的选择性改善。运动训练的大鼠表现出齿状回长时程增强的表达增强和物体识别学习的增强。Morris水迷宫中的空间学习不受运动的影响。这些变化与齿状回脑源性神经营养因子表达的增加有关。(c)2006 Elsevier B.V.保留所有权利。
Physical activity may have the potential to improve cognitive function. Here we show that forced treadmill-running results in selective improvements in hippocampal plasticity. Rats that underwent exercise training demonstrated enhanced expression of long-term potentiation in dentate gyrus and enhanced object recognition learning. Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus. (c) 2006 Elsevier B.V. All rights reserved.