Single-pulse electrical stimulation helps to identify epileptogenic cortex in children
Single-pulse electrical stimulation helps to identify epileptogenic cortex in children
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DOI：
10.1111/j.1528-1167.2009.02056.x
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发表时间：
2009-07-01
期刊：
影响因子：
5.6
通讯作者：
Boyd, Stewart G.
中科院分区：
文献类型：
--
作者：
Flanagan, Danny;Valentin, Antonio;Boyd, Stewart G.
目的：在儿科人群中评价单脉冲电刺激（SPES）在颅内记录中的有效性。这种方法是有用的，在识别癫痫皮质在成人subjects.Methods：我们研究了35名儿童进行颅内脑电图（EEG）记录从两家医院（国王学院医院和大奥蒙德街医院为患病儿童，伦敦，英国）。在每例患者中，我们使用一系列10个或更多个单一的，短暂的（1 ms）电刺激来研究所有可用的接触。详细回顾了皮层反应。的数据进行了检查之间的关联反应类型，发作区，病变边界，和癫痫outcome.Results：我们确定皮质反应SPES是类似的成人报告。与以前的研究一致，我们发现两种类型的反应（“延迟”和“重复”反应）与发作区和假定的致痫性病变区域相关。当这些反应是存在的（54%的情况下），删除负责SPES的异常反应的整个区域与良好的outcomet.Conclusion：皮质反应SPES在儿童癫痫手术评估过程中的致痫皮质在儿童的调查提供了新的和额外的信息。这可能会改善这个困难但重要的群体的结果。
P>Purpose:The usefulness of single-pulse electrical stimulation (SPES) during intracranial recordings was evaluated in a pediatric population. This method is useful in identifying epileptogenic cortex in adult subjects.Methods:We studied 35 children who were undergoing intracranial electroencephalography (EEG) recordings from two hospitals (King's College Hospital and Great Ormond Street Hospital for Sick Children, London, United Kingdom). In each patient we studied all available contacts using a series of 10 or more single, brief (1 ms) electrical stimuli. The cortical responses were reviewed in detail. The data were examined for associations between response type, ictal onset zone, lesion boundary, and seizure outcome.Results:We identified cortical responses to SPES that were similar to those reported in adults. In agreement with previous studies we found that two types of responses ("delayed" and "repetitive" responses) were associated with the ictal onset zone and the area of the presumed epileptogenic lesion. When these responses were present (54% of cases), the removal of the entire area responsible for the abnormal responses to SPES was associated with good outcome.Conclusion:Cortical responses to SPES in children provide new and additional information in the investigation of epileptogenic cortex in children during assessment for epilepsy surgery. This may improve the outcome for this difficult but important group.