Recent advances on the role of long non-coding RNA H19 in regulating mammalian muscle growth and development
Recent advances on the role of long non-coding RNA H19 in regulating mammalian muscle growth and development
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DOI：
10.16288/j.yczz.17-193
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Zhang, Hongping
中科院分区：
文献类型：
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作者：
Qin, Chenyu;Cai, He;Zhang, Hongping
H19是最早发现的长链非编码RNA（longnon-codingRNA，lncRNA）之一，在体内发挥着广泛的作用，不仅作为肿瘤抑制因子和癌基因参与疾病过程，而且作为哺乳动物胚胎多种组织生长发育的调节因子。1119在肌肉（骨骼肌和心肌）中的功能由于以下两个原因而引起广泛关注。一方面，H19通过顺式调节Igf 2，促进骨骼肌卫星细胞（SMSCs）的成肌分化和成肌。另一方面，H19还可以反式调节靶基因，包括海绵状let-7、miR-106或miR-29，以介导心肌细胞葡萄糖摄取、心肌细胞增殖和肌腱修复，以及通过与作为染色质修饰剂的MBD 1结合来促进胚胎发育和肌肉再生。本文就H19在哺乳动物肌肉中的作用进行综述，为进一步揭示肌肉生长发育的分子机制提供参考。
As one of the first identified long non-coding RNAs (lncRNAs), H19 plays a wide range of roles in vivo, including not only as a tumor suppressor and oncogene involved in disease process, but also as a regulator of growth and development of multiple tissues in mammalian embryos. The function of 1119 in muscles (both skeletal and cardiac muscle) draws widespread attention due to the following two reasons. On one hand, H19 promotes myogenic differentiation and myogenesis of skeletal muscle satellite cells (SMSCs) via regulating Igf2 in cis. On the other hand, H19 also modulates the target genes in trans, including sponging let-7, miR-106 or miR-29 to mediate myocyte glucose uptake, cardiomyocyte proliferation and tendon repair, as well as promote embryonic development and muscle regeneration through binding to MBD1 as a chromatin modifier. In this review, we summarize the role of H19 in mammalian muscles, which will provide a reference for further research to unveil the molecular mechanism of muscle growth and development.