Hippocampal place cells show increased sensitivity to changes in the local environment following prefrontal cortex lesions
Hippocampal place cells show increased sensitivity to changes in the local environment following prefrontal cortex lesions
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DOI：
10.1093/cercor/bhh173
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发表时间：
2005-06-01
期刊：
影响因子：
3.7
通讯作者：
Bilkey, DK
中科院分区：
文献类型：
--
作者：
Kyd, RJ;Bilkey, DK
研究表明，前额叶皮层通过抑制机制调节后额叶皮层的神经活动。因此，对前区的损伤可能会在后区产生抑制解除，并增加对外来信息的敏感性。这一假设是通过检查前额叶皮层损伤如何影响自由活动大鼠海马位置细胞的放电来研究的。在实验1中，病变组细胞的位置发射被改变到一个更大的程度比对照组细胞时，对象被引入到记录环境。这表明，位置细胞放电过度影响的局部线索在前额叶损伤的动物。在实验2中，记录位置细胞，而大鼠觅食的圆形轨道上访问本地和远端的多模态线索。虽然位置字段在病变组细胞的位置并没有过分依赖于当地的线索，更大比例的字段失去了空间选择性旋转这些线索。线索相关的影响与更大的细胞外动作电位振幅和更大的发病率在病变组细胞的爆发性放电。这一发现与前额叶皮层损伤导致后皮层抑制解除的假设一致。
It has been proposed that the prefrontal cortex modulates neural activity in posterior cortex via inhibitory mechanisms. As a result, damage to the former area may produce disinhibition in posterior regions and increase sensitivity to extraneous information. This hypothesis was investigated by examining how prefrontal cortex lesions affected the firing of hippocampal place cells in freely moving rats. In experiment 1, the positional firing of lesion-group cells was altered to a greater extent than that of control-group cells when objects were introduced into the recording environment. This suggested that place cell firing was overly influenced by local cues in the prefrontal-lesioned animals. In experiment 2 place cells were recorded while rats foraged on a circular track with access to both local and distal multimodal cues. Although the position of place fields in lesion-group cells was not excessively tied to local cues, a greater proportion of the fields lost their spatial selectivity following a rotation of these cues. The cue-related effects were associated with larger extracellular action-potential amplitudes and a greater incidence of burst-firing in lesion-group cells. This finding is consistent with the hypothesis that lesions of the prefrontal cortex result in a disinhibition of posterior cortex.