Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading
Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading
复制标题
DOI：
10.1677/erc-07-0126
复制
发表时间：
2008-03-01
影响因子：
3.9
通讯作者：
Manzoni, Marco F.
中科院分区：
文献类型：
--
作者：
Piani, Cecilia;Franchi, Giulia M.;Manzoni, Marco F.
超声内镜引导下细针穿刺细胞学检查（EUS-FNAC）采集的细胞学样本中Ki-67的表达可为胰腺内分泌肿瘤（PETS）的治疗提供术前指征。本研究的目的是评估EUS-FNAC在pet患者细胞学样本中检测Ki-67表达的可靠性。18例pet患者术前行EUS-FNAC检查。Ki-67在FNACs和组织切片上表达。使用2%的截断值，细胞学和组织学样本中Ki-67表达的一致性为89% （k统计量：0.78,95%置信区间（95% CI）： 0.5, 1.0）。使用截断值2和10%，一致性百分比为78% （k统计量：0.65,95% CI: 0.3, 0.9）。术前用EUS-FNAC检测细胞学样本中Ki-67的表达与组织学样本中Ki-67的表达一致。
The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETS) management. The aim of our study was to assess reliability of Ki-67 expression measured on cytological samples obtained by EUS-FNAC in patients with PETS. Eighteen patients with PETS underwent EUS-FNAC before surgery. Ki-67 expression was measured on FNACs and on histological sections. Using a cut-off of 2%, percent agreement of Ki-67 expression on cytological and histological samples was 89% (k-statistic: 0.78, 95% confidence intervals (95% CI): 0.5, 1.0). Using cut-off values of 2 and 10%, percent agreement was 78% (k-statistic: 0.65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples.