The Effect of Gender on Patients With Moderate to Severe Head Injuries
The Effect of Gender on Patients With Moderate to Severe Head Injuries
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DOI：
10.1097/ta.0b013e3181ba3354
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发表时间：
2009-11-01
影响因子：
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通讯作者：
Salim, Ali
中科院分区：
文献类型：
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作者：
Berry, Cherisse;Ley, Eric J.;Salim, Ali
背景：男性和女性神经系统对创伤性脑损伤的反应不同，体内研究表明这种差异与女性性激素的神经保护作用有关。在临床研究中复制女性性激素相关神经保护的尝试一直未获成功。本研究的目的是确定性别或绝经状况是否影响中重度颅脑损伤患者的死亡率。方法：使用国家创伤数据库6.2版(2000-2005)的数据对所有孤立的中重度颅脑损伤患者进行了回顾性研究。在无明显颅外损伤的患者中，孤立性颅脑损伤定义为头部缩写损伤评分(缩写损伤评分)
Background: Male and female nervous systems respond differently to traumatic brain injury (TBI) and in vivo research relates this difference to neuroprotection from female sex hormones. Attempts to replicate female sex hormone-related neuroprotection in clinical studies have been unsuccessful. The objective of this study was to determine whether gender or menopausal status affects mortality in patients with moderate to severe TBI.Methods: A retrospective review of all patients with isolated moderate to severe TBI was undertaken using data from the National Trauma Database version 6.2 (2000-2005). Isolated TBI was defined as head Abbreviated Injury Score >= 3 in patients without significant extracranial injuries (Abbreviated Injury Score