Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid.
Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid.
复制标题
丙戊酸抑制原型沙粒病毒 LCMV 的增殖。
DOI：
10.1016/j.antiviral.2013.05.012
复制
发表时间：
2013
影响因子：
7.6
通讯作者：
delaTorre,JuanCarlos
中科院分区：
文献类型：
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作者：
Vázquez-Calvo,Ángela;Martín-Acebes,MiguelA;Sáiz,Juan-Carlos;Ngo,Nhi;Sobrino,Francisco;delaTorre,JuanCarlos
丙戊酸（VPA）是一种常用于治疗神经系统疾病的短链脂肪酸，已被证明可以抑制不同包膜病毒（包括原型沙粒病毒淋巴细胞性脉络膜脑膜炎病毒（LCMV））的感染性后代的产生。在这项研究中，我们研究了 VPA 抑制培养细胞中 LCMV 增殖的机制。 VPA 减少了感染性 LCMV 后代的产生和病毒传播，但没有对病毒 RNA 或蛋白质合成产生重大阻碍，而是影响受感染细胞的 LCMV 后代的细胞释放和特异性感染性。我们的结果将支持将 VPA 重新用作对抗沙粒病毒感染的候选抗病毒药物。
Valproic acid (VPA), a short chain fatty acid commonly used for treatment of neurological disorders, has been shown to inhibit production of infectious progeny of different enveloped viruses including the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). In this study we have investigated the mechanisms by which VPA inhibits LCMV multiplication in cultured cells. VPA reduced production of infectious LCMV progeny and virus propagation without exerting a major blockage on either viral RNA or protein synthesis, but rather affecting the cell release and specific infectivity of LCMV progeny from infected cells. Our results would support the repurposing of VPA as a candidate antiviral drug to combat arenavirus infections.