Exposure to the Chinese famine in early life and the risk of hypertension in adulthood
Exposure to the Chinese famine in early life and the risk of hypertension in adulthood
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DOI：
10.1097/hjh.0b013e328345d969
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发表时间：
2011-06-01
影响因子：
4.9
通讯作者：
Ma, Guansheng
中科院分区：
文献类型：
--
作者：
Li, Yanping;Jaddoe, Vincent W.;Ma, Guansheng
目的母亲饥饿暴露与后代高血压有关。本研究的目的是研究协会的早期生活暴露于1959-1961年的中国饥荒与高血压的风险，在以后的生活中，并研究是否营养丰富的环境在以后的生活修改此association.Methods我们使用的数据7874年之间出生的成年人1954年和1964年从2002年中国国民营养与健康调查。结果在严重饥荒区，与未受饥荒影响的成年人相比，胎儿期受饥荒影响的成年人收缩压（SBP）显著升高[SBP差值2.2mmHg，95%可信区间（CI）1.3-3.0，P
Objectives Maternal famine exposure has been associated with higher blood pressure in the offspring. The aim of the present study was to examine the associations of early life exposure to the 1959-1961 Chinese famine with the risk of hypertension in later life, and to examine whether a nutritional 'rich' environment in later life modifies this association.Methods We used data of 7874 adults born between 1954 and 1964 from the 2002 China National Nutrition and Health Survey. Excess death rate was used to determine the severity of the famine.Results In severely affected famine areas, as compared to adults who were not exposed to famine, those exposed during fetal life had a significantly higher SBP [SBP difference 2.2 mmHg, 95% confidence interval (CI) 1.3-3.0, P