Development of fibrous biodegradable polymer conduits for guided nerve regeneration
Development of fibrous biodegradable polymer conduits for guided nerve regeneration
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DOI：
10.1007/s10856-005-0637-6
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发表时间：
2005-04-01
影响因子：
3.7
通讯作者：
Ramakrishna, S
中科院分区：
文献类型：
--
作者：
Bini, TB;Gao, SJ;Ramakrishna, S
微编织技术是一种新型的神经组织工程用纤维管状支架的制备方法。本研究中使用的生物可降解聚合物是聚（L-丙交酯-共-乙交酯）（10：90）和壳聚糖。将聚合物纤维微编织在Teflon心轴周围以使其成为管状结构。然后研究了导管的表面形态、膨胀行为和生物相容性。通过扫描电子显微镜分析表面形态，通过吸水引起的重量增加分析溶胀行为，通过聚合物浸提液处理细胞的MTT试验在细胞形态和细胞活力方面进行体外细胞毒性评估分析生物相容性。这些导管也可用于组织的再生，其需要管状支架，例如血管、脊髓、肠等。
The technique of microbraiding with modification was employed as a novel method for the fabrication of fibrous tubular scaffolds for nerve tissue engineering purposes. The biodegradable polymers used in this study were poly(L-lactide-co-glycolide) ( 10: 90) and chitosan. The polymeric fibers were microbraided around a Teflon mandrel to make it as a tubular construct. The conduits were then studied for their surface morphology, swelling behaviour and biocompatibility. The surface morphology was analysed by scanning electron microscope, swelling behaviour by weight increase due to water uptake and biocompatibility by in vitro cytotoxicity assessment in terms of cell morphology and cell viability by the MTT assay of polymer extract treated cells. These conduits may also be used for regeneration of tissues, which require tubular scaffolds such as blood vessel, spinal cord, intestine etc. (C) 2005 Springer Science + Business Media, Inc.