Evaluation of TNF-α and IL-6 Levels in Obese and Non-obese Diabetics: Pre- and Postinsulin Effects.
Evaluation of TNF-α and IL-6 Levels in Obese and Non-obese Diabetics: Pre- and Postinsulin Effects.
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DOI：
10.4103/1947-2714.94944
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Singhai M
中科院分区：
文献类型：
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作者：
Goyal R;Faizy AF;Siddiqui SS;Singhai M
2型糖尿病（T2 DM）是肥胖的严重并发症。胰岛素治疗对肥胖和非肥胖糖尿病患者炎症标志物水平的影响尚未得到充分研究。本研究旨在分析非肥胖和肥胖T2 DM患者胰岛素前和胰岛素后肿瘤坏死因子α（TNF-α）和IL-6水平。我们评估了健康对照组（n=10）和糖尿病患者（肥胖和非肥胖;各n=20）的TNF-α和IL-6水平，并分析了24周和48周后胰岛素治疗对TNF-α和IL-6水平的影响。肥胖和非肥胖糖尿病患者胰岛素治疗后TNF-α和IL-6水平与空腹血糖也有相关性。糖尿病患者TNF-α和IL-6水平升高，肥胖糖尿病患者升高程度高于非肥胖糖尿病患者。肥胖组治疗24周后TNF-α和IL-6水平显著降低（P <0.05），治疗48周后TNF-α和IL-6水平极显著降低（P<0.001）。非肥胖组TNF-α和IL-6水平在24周和48周后均极显著降低（P<0.001）。糖尿病患者的炎症反应会增强，肥胖糖尿病患者的炎症反应更严重。胰岛素治疗往往对抗这种炎症，但在肥胖糖尿病患者中反应延迟。
Type 2 diabetes (T2DM) mellitus is a serious implication of obesity. The effect of insulin therapy on levels of inflammatory markers among obese and non-obese diabetics has been inadequately studied. The study aimed to analyze the preinsulin and postinsulin levels of tumor necrosis factor α (TNF-α) and IL-6 in nonobese and obese T2DM patients. We assessed TNF-α and IL-6 levels in healthy controls (n=10) and diabetic patients (obese and nonobese; n=20 each) and analyzed the postinsulin effect on TNF-α and IL-6 levels after 24 and 48 weeks. TNF-α and IL-6 levels were also correlated with fasting plasma glucose of obese and nonobese diabetic patients after insulin therapy. There is augmentation of TNF-α and IL-6 levels in diabetic patients and augmentation is more in obese than in nonobese diabetics. The obese group showed a significant decrease (P value<0.05) after 24 weeks of insulin therapy and an extremely significant decrease (P<0.001) in TNF-α and IL-6 levels after 48 weeks of therapy. The nonobese group showed an extremely significant decrease (P<0.001) in TNF-α and IL-6levels after 24 and 48 weeks both. There is augmented inflammation in diabetes and it is more in obese diabetics. Insulin therapy tends to counter this inflammation, but the response is delayed in obese diabetics.