The Michigan State University Twin Registry (MSUTR): 15 Years of Twin and Family Research
The Michigan State University Twin Registry (MSUTR): 15 Years of Twin and Family Research
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DOI：
10.1017/thg.2019.57
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发表时间：
2019-12-01
影响因子：
0.9
通讯作者：
Klump, Kelly L.
中科院分区：
文献类型：
--
作者：
Burt, S. Alexandra;Klump, Kelly L.
密歇根州立大学双胞胎登记处（MSUTR）的主要目的是研究遗传、环境、神经、表观遗传和神经生物学对精神病理学和复原力的影响，特别是在儿童和青少年时期。MSUTR有两个广泛的组成部分：一个大规模的，以人口为基础的儿童，青少年和成年双胞胎及其家庭的登记（目前N 30，000）和一系列更集中和深入的研究从登记（预计N 7200）。在基于人口的登记处的参与者通过邮件完成家庭健康和人口统计调查问卷。然后，可以使用几种招募策略中的任何一种（例如，基于人口，基于他们对登记册调查问卷的答复）。这些后者的研究针对各种生物学，遗传学和环境表型，包括精神和行为表型的多信息测量，功能和结构神经成像，双胞胎家庭环境的综合测量（例如，双胞胎邻居特征的人口普查和邻居线人报告、儿童双胞胎家庭的录像互动）、口腔拭子和唾液DNA样本和/或青少年和成人类固醇激素水平的测定。本文概述了MSUTR，并介绍了当前和未来的研究方向。
The primary aim of the Michigan State University Twin Registry (MSUTR) is to examine developmental differences in genetic, environmental, neural, epigenetic, and neurobiological influences on psychopathology and resilience, particularly during childhood and adolescence. The MSUTR has two broad components: a large-scale, population-based registry of child, adolescent, and adult twins and their families (current N 30,000) and a series of more focused and in-depth studies drawn from the registry (projected N 7200). Participants in the population-based registry complete a family health and demographic questionnaire via mail. Families can then be recruited for one or more of the intensive, in-person studies from the population-based registry, using any one of several recruitment strategies (e.g., population-based, based on their answers to the registry questionnaire). These latter studies target a variety of biological, genetic, and environmental phenotypes, including multi-informant measures of psychiatric and behavioral phenotypes, functional and structural neuroimaging, comprehensive measures of the twin family environment (e.g., census and neighborhood informant reports of twin neighborhood characteristics, videotaped interactions of child twin families), buccal swab and salivary DNA samples, and/or assays of adolescent and adult steroid hormone levels. This article provides an overview of the MSUTR and describes current and future research directions.