Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis.
Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis.
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尿碘浓度（UIC）可能是预测学龄儿童甲状腺肿的一个有前途的生物标志物：系统评价和荟萃分析
DOI：
10.1371/journal.pone.0174095
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Xiu L;Zhong G;Ma X
目的探讨尿碘浓度（UIC）对学龄儿童甲状腺肿大的预测作用，并探讨UIC与甲状腺肿大患病率的关系。方法计算机检索MEDLINE、EMBASE、科克伦图书馆（科克伦系统评价数据库）、Web of Science、CNKI、维普、万方数据库，检索截止日期为2016年8月25日的中英文相关报道。计算UIC和甲状腺肿患病率评估的平均差异（MD）和95%置信区间（CI）。合并优势比和95%CI用于比较不同UIC组中甲状腺肿的患病率。结果11项病例对照研究发现，甲状腺肿大儿童UIC值低于非甲状腺肿大儿童（MD：-1.82，95%CI：-3.24，-0.40，p < 0.05）。甲状腺肿风险增加与UIC值< 20 μg/L或> 200 μg/L相关。结论低UIC值与甲状腺肿大风险增加相关，碘缺乏可能导致甲状腺肿大风险增加。此外，我们观察到UIC与甲状腺肿患病率之间的U形关系，这表明严重碘缺乏和过量碘摄入都可能导致甲状腺肿风险增加。
Objectives To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. Methods We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Pooled odds ratios and 95% CIs were used to compare the prevalences of goiter in the different UIC groups. Results We identified 11 case-control studies, and found that children with goiter had lower UIC values, compared to children without goiter (MD: –1.82, 95% CI: –3.24, –0.40, p < 0.05). An increased risk of goiter was associated with UIC values of < 20 μg/L or > 200 μg/L. Conclusion The results of our meta-analysis suggest that lower UIC values were associated with an increased risk of goiter, and that iodine deficiency may lead to an increased risk of goiter. Furthermore, we observed U-shaped relationships between UIC and the prevalence of goiter, which suggests that both severe iodine deficiency and excessive iodine intake may lead to increased risks of goiter.