Systems biology: confronting the complexity of cancer.
Systems biology: confronting the complexity of cancer.
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DOI：
10.1158/0008-5472.can-11-1569
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发表时间：
2011-09-15
期刊：
影响因子：
11.2
通讯作者：
Gallahan D
中科院分区：
文献类型：
--
作者：
Gentles AJ;Gallahan D
AACR-NCI会议“系统生物学：“面对癌症的复杂性”会议于2011年2月27日至3月2日在加州圣地亚哥举行。会议期间有几个主题引起了共鸣，特别是(a)需要更好的方法来从大规模网络中提取见解，(b)在构建更现实的模型中整合多种数据类型的重要性，(c)将关于肿瘤发生机制的见解转化为治疗干预的挑战，以及(d)肿瘤微环境的作用，在物理上，细胞和分子水平。会议强调了系统生物学在癌症方面的具体应用，以及跨学科研究人员在解决棘手问题方面的合作价值。
The AACR-NCI Conference “Systems Biology: Confronting the Complexity of Cancer” took place from February 27 to March 2, 2011 in San Diego, CA. Several themes resonated during the meeting, notably (a) the need for better methods to distill insights from large-scale networks, (b) the importance of integrating multiple data types in constructing more realistic models, (c) challenges in translating insights about tumorigenic mechanisms into therapeutic interventions, and (d) the role of the tumor microenvironment, at the physical, cellular, and molecular levels. The meeting highlighted concrete applications of systems biology to cancer, and the value of collaboration between interdisciplinary researchers in attacking formidable problems.