Comparison of statistical methods of analysis of data from clinical periodontal trials.
Comparison of statistical methods of analysis of data from clinical periodontal trials.
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临床牙周试验数据分析统计方法的比较。
DOI：
10.1111/j.1600-051x.1983.tb01273.x
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发表时间：
1983
影响因子：
6.7
通讯作者：
Lindhe,J
中科院分区：
文献类型：
--
作者：
Haffajee,AD;Socransky,SS;Lindhe,J
临床试验的数据通常是通过寻找不同治疗方法组的临床测量方法之间的差异来分析的。这些差异可能很难在临床上解释，也无法向研究人员或临床医生提供有意义的信息。从一组维护良好的患者身上获得的附着水平测量，最初通过刮除或Widman瓣手术进行治疗，被人为操纵，以将已知的变化强加于刮除的组。个别站点的数据通过t检验和Mann-Whitney检验进行分析；频率分布通过Kolmogorov-Smirnov 2样本检验和Ridit分析进行分析；极端反应的摩西检验寻求极端变化，并通过创建列联表来消除低于任意变化阈值的变化。对结果的检验表明，平均值对大量站点的微小变化敏感，但对较少站点的重大变化不敏感。由于后一种变化可能对研究人员和临床医生有重要意义，建议在平均值(或中位数)的基础上显示变化的频率分布，并在少数站点进行寻找大变化的分析。
Data from clinical trials have commonly been analyzed by seeking differences between means of clinical measurements in groups treated in different ways. Such differences may be difficult to interpret clinically and fail to impart meaningful information to the research worker or clinician.Attachment level measurements taken from a group of well‐maintained patients, initially treated by either scaling or Widman flap surgery, were artificially manipulated to impose known changes on the scaled group. Data from individual sites were analyzed by the t‐test and Mann‐Whitney test; and frequency distributions by the Kolmogorov‐Smirnov 2‐sample lest and ridit analysis, Extreme changes were sought by the Moses test for extreme reactions and by creating contingency tables in which changes below arbitrary thresholds of change were eliminated. Examination of the results indicated that the mean was sensitive to small changes in large numbers of sites but insensitive to major changes in a smaller number of sites. Since the latter changes may be of significance to the research worker and clinician, it is recommended that the mean (or median values) be supplemented with the presentation of the frequency distribution of changes and an analysis seeking large changes in few sites.