Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study
Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study
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DOI：
10.1016/s0140-6736(00)02784-7
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发表时间：
2000-10-07
期刊：
影响因子：
168.9
通讯作者：
Jick, H
中科院分区：
文献类型：
--
作者：
Zornberg, GL;Jick, H
背景 抗精神病药物与静脉血栓栓塞等不良事件的风险增加有关。我们的目的是评估首次被诊断患有特发性静脉血栓栓塞的传统抗精神病药物使用者的这种风险。方法从 29,952 名年龄小于 60 岁的常规和非典型抗精神病药物接受者的基线人群中，我们确定了 42 名特发性静脉血栓栓塞患者和 172 名匹配的对照者。我们比较了病例和对照中当前和近期使用抗精神病药物与索引日期前不使用抗精神病药物的风险。结果与不使用相比，当前使用传统抗精神病药物与特发性静脉血栓栓塞风险显着增加相关（调整后比值比 7.1 [95% CI 2.3-21.97]）。尽管我们发现吩噻嗪类、噻吨类或其他常规抗精神病药物之间没有差异，但氯丙嗪和硫利达嗪等低效抗精神病药物与静脉血栓栓塞的相关性比氟哌啶醇等高效抗精神病药物更强（比值比 24.1 [3.3-172.7]）。 [0.8-13.2]）。在使用传统抗精神病药物的最初几个月内，静脉血栓形成的风险最高。 解释 目前使用传统抗精神病药物会显着增加 60 岁以下男性和女性发生特发性静脉血栓栓塞的风险。
Background Antipsychotic drugs have been associated with an increased risk of adverse events such as venous thromboembolism. Our aim was to assess this risk in users of conventional antipsychotic drugs who had been diagnosed with first-time, idiopathic venous thromboembolism.Methods From a baseline population of 29 952 recipients of conventional and atypical antipsychotic drugs aged younger than 60 years, we identified 42 individuals with idiopathic venous thromboembolism and 172 matched controls. We compared risk of current and recent use of antipsychotic drugs with non-use before the index date in cases and controls.Findings Current exposure to conventional antipsychotic drugs was associated with a significantly increased risk of idiopathic venous thromboembolism compared with nonuse (adjusted odds ratio 7.1 [95% CI 2.3-21.97]). Although we found no difference between phenothiazines, thioxanthenes, or other conventional antipsychotic drugs, low potency antipsychotic drugs drugs such as chlorpromazine and thioridazine were more strongly associated with venous thromboembolism (odds ratio 24.1 [3.3-172.7]) than were high potency antipsychotic drugs such as haloperidol (3.3 [0.8-13.2]). The risk for Venous thrombosis was highest during the first few months of conventional antipsychotic drug use.Interpretation Current exposure to conventional antipsychotic drugs significantly increases the risk of idiopathic Venous thromboembolism in men and women younger than 60 years of age.