The host response to herpes simplex virus infection
The host response to herpes simplex virus infection
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宿主对单纯疱疹病毒感染的反应
DOI：
--
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发表时间：
2004
影响因子：
3.9
通讯作者：
B. Chain
中科院分区：
文献类型：
--
作者：
G. Pollara;D. Katz;B. Chain
单纯疱疹病毒感染仍然是该病的重要病因。宿主免疫系统在抑制病毒复制中起着重要作用，在确定哪些免疫成分是解决感染的关键方面已经取得了相当大的进展。然而，有效的免疫预防或免疫治疗尚未实现。最近的研究工作集中在了解导致单纯疱疹病毒特异性免疫反应的早期事件，特别是抗原呈递树突状细胞的作用。单纯疱疹病毒已经进化出许多干扰树突状细胞抗原呈递的方法，从而可能阻碍或延迟宿主的免疫反应。然而，单纯疱疹病毒引发了强大的细胞和体液免疫。树突状细胞吸收死亡或垂死的感染细胞并将其交叉呈递给同源T细胞的能力可能是解决这一明显矛盾的关键。树突状细胞亚群之间的相互作用，特别是病毒诱导的I型干扰素的释放，可能是驱动有效抗原交叉呈递和随后的t细胞活化所必需的。对树突状细胞在驱动病毒免疫中的重要性，以及激活这些细胞的配体和它们分泌的细胞因子的更深入的了解，提供了新的疫苗接种策略。将免疫调节基因与病毒抗原一起递送，例如通过DNA疫苗接种，可以充分利用树突状细胞的潜力，实现对单纯疱疹病毒进行有效免疫控制的目标。
Purpose of review Infection with herpes simplex virus remains a significant cause of disease. The host immune system plays an important role in containing viral replication, and there has been considerable progress in defining which components of immunity are key to the resolution of infection. Nevertheless, effective immunoprophylaxis or immunotherapy has not yet been achieved. Recent findings Recent work has focused on understanding the early events leading to the herpes simplex virus-specific immune response, in particular on the role of antigen-presenting dendritic cells. Herpes simplex virus has evolved a number of ways of interfering with antigen presentation by dendritic cells, thus presumably impeding or delaying the host immune response. Nevertheless, herpes simplex virus triggers strong cellular and humoral immunity. The ability of dendritic cells to take up dead or dying infected cells and cross-present them to cognate T cells may be the key to resolving this apparent paradox. Interaction between dendritic cell subsets, and particularly the virus-induced release of type I interferons may be essential to drive efficient antigen cross-presentation and subsequent T-cell activation. Summary A greater understanding of the importance of dendritic cells in driving viral immunity, and of the ligands that activate these cells and the cytokines they secrete, has provided novel vaccination strategies. The delivery of immunomodulatory genes together with viral antigens, for example by DNA vaccination, may harness the full potential of dendritic cells, and achieve the goal of effective immunological control of herpes simplex virus.
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影响因子：
120.7
作者：
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通讯作者：
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影响因子：
32.4
作者：
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20.3
作者：
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影响因子：
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作者：
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通讯作者：
Blum,JaniceS