Comparative genomic organization of the cbl genes
Comparative genomic organization of the cbl genes
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DOI：
10.1016/s0378-1119(03)00471-2
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发表时间：
2003-04-10
期刊：
影响因子：
3.5
通讯作者：
Lipkowitz, S
中科院分区：
文献类型：
--
作者：
Nau, MM;Lipkowitz, S
通过克隆和数据库搜索的结合确定了来自多种哺乳动物和非哺乳动物物种的 cbl 基因的基因组组织。人类和小鼠具有三个 cbl 基因（c-cbl、(1) cblb 和 cblc），这些基因在编码包括环指在内的蛋白质的高度保守的 N 末端区域的基因区域上显示出内含子/外显子结构的显着保守性。对基因组、cDNA 和 EST 数据库的搜索表明，脊索动物、昆虫和蠕虫中存在一种或多种 cbl 基因。对 cbl 基因家族的复杂性和基因组组织以及来自不同物种的预测 Cbl 蛋白的比较表明，这三个哺乳动物 cbl 基因是由祖先基因的两次重复产生的。来自不同物种的 cbl 基因的基因组组织提供了对 cbl 基因家族进化的深入了解。 (C) 2003 Elsevier Science B.V. 保留所有权利。
The genomic organization of cbl genes from a variety of mammalian and non-mammalian species was determined by a combination of cloning and database searches. Humans and mice have three cbl genes (c-cbl,(1) cblb, and cblc) which show remarkable conservation of the intron/exon structure over the region of the genes which encode the highly conserved N-terminal region of the proteins including the RING finger. Searches of genomic, cDNA, and EST databases revealed that one or more cbl genes exist in chordates, insects, and worms. Comparison of the complexity and genomic organization of the cbl gene family and the predicted Cbl proteins from various species suggests that the three mammalian cbl genes arose by two duplications of an ancestral gene. The genomic organization of the cbl genes from various species provides insight into the evolution of the cbl gene family. (C) 2003 Elsevier Science B.V. All rights reserved.