Synthesis of Photoluminescent ZnO Quantum Dots and Its Application in Bioimaging
Synthesis of Photoluminescent ZnO Quantum Dots and Its Application in Bioimaging
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光致发光ZnO量子点的合成及其在生物成像中的应用
DOI：
10.1166/nnl.2017.2515
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发表时间：
2017
影响因子：
--
通讯作者：
Polly H. M. Leung
中科院分区：
文献类型：
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作者：
Shuihong Li;Qianqian Mou;Polly H. M. Leung
在过去的几十年里，氧化锌纳米结构的应用引起了越来越多的研究兴趣。然而，基于氧化锌纳米粒子的多模式肿瘤显像剂的研究进展有限。本工作研究了乙醇分散的氧化锌量子点的合成及其体外生物成像效应。氧化锌量子点的合成是基于水诱导的胺的质子化。由于制备过程是在常规条件下(室温、常压、中性pH)进行的，因此合成路线简单，成本较低。合成的氧化锌量子点(平均直径为4 5 nm)在紫外光激发下(λex：32 5 nm)在385 nm附近有一个宽而强的紫外发射峰。傅里叶变换红外光谱(FTIR)结果表明，纳米团簇的表面被胺/PVP覆盖，形成了ZnO@胺/PVP核壳结构。当氧化锌量子点进入细菌和癌细胞时，产生了意想不到的明亮的蓝色荧光信号。这增加了将氧化锌量子点用于荧光生物成像的可能性。
The applications of zinc oxide (ZnO) nanostructures have gained increasing research interests in the past decades. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. This work presented synthesis and in vitro bioimaging effect of ethanol dispersed ZnO quantum dots (QDs). The synthesis of ZnO QDs is based on the water-induced protonation of amines. The synthesis pathway was simple and less cost because the preparation process was under routine conditions (room temperature, atmosphere pressure and neutral pH). The synthesized ZnO QDs (mean diameters of 4.5 nm) exhibited a broad and strong ultraviolet emission peak centered near 385 nm under ultraviolet excitation (λ ex: 325 nm). The results of fourier transform infrared (FTIR) spectra indicated that the surface of ZnO nanocluster were capped by amine/PVP, and formed ZnO@amine/PVP core–shell. The unanticipated bright blue fluorescence signals were generated when the ZnO QDs entered into the bacterial and cancer cells. This raised the possibility that ZnO QDs can be used for fluorescence bio-imaging.