LEUKOKINETIC STUDIES. X. BLOOD GRANULOCYTE KINETICS IN CHRONIC MYELOCYTIC LEUKEMIA.
LEUKOKINETIC STUDIES. X. BLOOD GRANULOCYTE KINETICS IN CHRONIC MYELOCYTIC LEUKEMIA.
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白细胞动力学研究。
DOI：
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发表时间：
1965
影响因子：
15.9
通讯作者：
M. Wintrobe
中科院分区：
文献类型：
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作者：
J. Athens;S. Raab;O. Haab;D. Boggs;H. Ashenbrucker;G. Cartwright;M. Wintrobe
通过输注体外用氟磷酸二异丙酯（DFP 32）标记的粒细胞，可以测量总血液粒细胞池（TBGP）的大小、粒细胞在其两个亚室中的分布、血液粒细胞半消失时间（tj）和血液粒细胞周转率（GTR）（1-3）。在本实验室的初步报告（4-6）和其他实验室的报告（7，8）中，在少数慢性粒细胞白血病患者中描述了TBGP大小增加、血粒细胞ti延长和GTR增加。在本报告中，对29例慢性粒细胞白血病（CML）患者在其疾病的不同阶段进行了43项研究，试图获得这些偏离正常粒细胞动力学的理解。此外，还介绍了几项旨在评价CML患者t4值较长原因的研究。在真性红细胞增多症、亚急性或慢性感染、骨髓纤维化或其他类型疾病患者的粒细胞动力学的类似研究在一篇配套论文中提出。
By the transfusion of granulocytes labeled in vitro with diisopropyl fluorophosphate (DFP32), it is possible to measure the size of the total blood granulocyte pool (TBGP), the distribution of granulocytes in the two subcompartments thereof, the blood granulocyte half disappearance time (tj), and the blood granulocyte turnover rate (GTR) (1-3). In preliminary reports from this laboratory (4-6) and in reports from other laboratories (7, 8) an increase in TBGP size, prolongation of blood granulocyte ti, and an increase in GTR have been described in a few patients with chronic myelocytic leukemia. In the present report 43 studies carried out on 29 patients with chronic myelocytic leukemia (CML) in various stages of their disease have been analyzed in an attempt to gain an understanding of these deviations from normal granulocyte kinetics. In addition, several studies designed to evaluate the cause of the long t4 values in patients with CML are presented. Similar studies of granulocyte kinetics in patients with polycythemia vera, subacute or chronic infections, myelofibrosis, or diseases of other kinds are presented in a companion paper.