Measuring temporal dynamics of resting-state fMRI data.
Measuring temporal dynamics of resting-state fMRI data.
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DOI：
10.3233/bme-130888
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发表时间：
2014
影响因子：
1
通讯作者：
Lianghua He;D. Hu;Meng Wan;Y. Wen
中科院分区：
文献类型：
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作者：
Lianghua He;D. Hu;Meng Wan;Y. Wen
静息状态功能磁共振成像(rs-fmri)用于测量静息状态下大脑的血氧水平依赖(BOLD)，是一种相对较新和有效的方法，用于评估当参与者没有执行明确任务时发生的区域相互作用。由于BOLD记录对相移和时程长度的敏感性，基于感兴趣区的传统相关和相干方法不再适用于RS-fMRI分析。在本文中，我们提出了一种更稳健和一致的方法，即主频映射，来分析RS-fMRI数据。我们发现，在休息的人脑中，大胆记录的主要频率为0.0137赫兹，这在参与者和大脑区域之间是一致的。这种频率主要分布在控制人类社会行为、情绪和决策的脑回直肌、额内侧眶、额上眶和嗅沟。与此同时，我们发现，BOLD频率在中央前回、额上回、脑岛、尾状核、壳核和部分小脑的脑区最不一致，这些脑区的功能与运动有关。
Resting state functional MRI (rs-fMRI), which is used to measure blood oxygen level-dependent (BOLD) from resting brains, is a relatively new and powerful method for evaluating regional interactions that occur when a participant is not performing an explicit task. Because of the sensitiveness to the phase shift and length of time courses of the BOLD recordings, region of interest based conventional correlation and coherence methods are no longer suitable for rs-fMRI analyses. In this paper, we propose a more robust and consistent method, dominant frequency mapping, to analyze rs-fMRI data. We found a dominant frequency of BOLD recordings, 0.0137 Hz, in resting human brains that is consistent across participants and brain regions. This frequency is detected mainly in Gyrus Rectus, Frontal Medial Orbital, Frontal Superior Orbital and Olfactory Sulcus, which control the human social behavior, emotion, and decision making. In the meantime, we found that BOLD frequencies are most inconsistent in the brain regions of PrecentralGyrus, Superior Frontal gyrus, Insula, Caudate nucleus, Putamen, and part of the cerebellum, whose functions are about motor.