INHIBITORY EFFECT OF A SYNTHETIC POLYPEPTIDE, POLY(TYR-ILE-GLY-SER-ARG), ON THE METASTATIC FORMATION OF MALIGNANT-TUMOR CELLS
INHIBITORY EFFECT OF A SYNTHETIC POLYPEPTIDE, POLY(TYR-ILE-GLY-SER-ARG), ON THE METASTATIC FORMATION OF MALIGNANT-TUMOR CELLS
复制标题
DOI：
10.1016/0141-8130(89)90049-4
复制
发表时间：
1989-04-01
影响因子：
8.2
通讯作者：
NISHI, N
中科院分区：
文献类型：
--
作者：
MURATA, J;SAIKI, I;NISHI, N
用叠氮磷酸二苯酯（DPPA）聚合法合成了一种含有层粘连蛋白细胞粘附位点重复序列的新型多肽--聚（Tyr-Ile-Gly-Ser-Arg）。我们发现这种多肽比五肽更有效地抑制恶性肿瘤细胞在肺中的转移形成。
A new type of polypeptide containing the repeating sequence of cell attachment site in laminin, poly(Tyr-Ile-Gly-Ser-Arg), was synthesized by the polymerization procedure with diphenylphoshoryl azide (DPPA). We found that this polypeptide inhibited the metastatic formation in the lung of malignant tumour cells for more effectively than pentapeptide.