Galectin-3 in Cardiovascular Diseases.
Galectin-3 in Cardiovascular Diseases.
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DOI：
10.3390/ijms21239232
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发表时间：
2020-12-03
影响因子：
5.6
通讯作者：
Fortunato G
中科院分区：
文献类型：
--
作者：
Blanda V;Bracale UM;Di Taranto MD;Fortunato G
半乳糖凝集素-3（Galectin-3，Gal-3）是一种β-半乳糖苷结合蛋白，属于凝集素家族，具有多种调节活性和多种生理细胞功能，如细胞生长、增殖、凋亡、分化、细胞粘附和组织修复。炎症、组织纤维化和血管生成是Gal-3参与的主要过程。它涉及几种疾病的发病机制，包括器官纤维化、慢性炎症、癌症、动脉粥样硬化和其他心血管疾病（CVD）。本文综述了Gal-3与心血管疾病的关系，因为它们是发病和死亡的主要原因。我们在此讨论了Gal-3在致动脉粥样硬化过程中的促炎作用以及与斑块特征和病变稳定性的相关性。我们报告了Gal-3在其他心血管疾病中的生物学作用和分子机制，强调其参与心脏纤维化和心肌重塑受损的发展，导致心力衰竭和房颤。Gal-3作为心力衰竭的预后标志物的作用与其他CVD的可能诊断应用一起描述。最后，我们报告了Gal-3抑制作为预防心脏炎症和纤维化的治疗方法的尝试性用途。
Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with pleiotropic regulatory activities and several physiological cellular functions, such as cellular growth, proliferation, apoptosis, differentiation, cellular adhesion, and tissue repair. Inflammation, tissue fibrosis and angiogenesis are the main processes in which Gal-3 is involved. It is implicated in the pathogenesis of several diseases, including organ fibrosis, chronic inflammation, cancer, atherosclerosis and other cardiovascular diseases (CVDs). This review aims to explore the connections of Gal-3 with cardiovascular diseases since they represent a major cause of morbidity and mortality. We herein discuss the evidence on the pro-inflammatory role of Gal-3 in the atherogenic process as well as the association with plaque features linked to lesion stability. We report the biological role and molecular mechanisms of Gal-3 in other CVDs, highlighting its involvement in the development of cardiac fibrosis and impaired myocardium remodelling, resulting in heart failure and atrial fibrillation. The role of Gal-3 as a prognostic marker of heart failure is described together with possible diagnostic applications to other CVDs. Finally, we report the tentative use of Gal-3 inhibition as a therapeutic approach to prevent cardiac inflammation and fibrosis.
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影响因子：
5.6
作者：
Clementy N;Piver E;Bisson A;Andre C;Bernard A;Pierre B;Fauchier L;Babuty D
通讯作者：
Babuty D
影响因子：
5.3
作者：
Di Taranto, Maria Donata;Morgante, Alberto;Salvatore, Francesco
通讯作者：
Salvatore, Francesco
影响因子：
24
作者：
Asleh, Rabea;Enriquez-Sarano, Maurice;Roger, Veronique L.
通讯作者：
Roger, Veronique L.
影响因子：
5.3
作者：
Bambouskova, Monika;Polakovicova, Iva;Draber, Petr
通讯作者：
Draber, Petr
影响因子：
--
作者：
Averna, Maurizio;Cefalu, Angelo B.;Tarugi, Patrizia
通讯作者：
Tarugi, Patrizia