MR imaging phenotype correlates with extent of genome-wide copy number abundance in IDH mutant gliomas.
MR imaging phenotype correlates with extent of genome-wide copy number abundance in IDH mutant gliomas.
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DOI：
10.1007/s00234-019-02219-8
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发表时间：
2019-09
期刊：
影响因子：
2.8
通讯作者：
Snuderl M
中科院分区：
文献类型：
--
作者：
Wu CC;Jain R;Neto L;Patel S;Poisson LM;Serrano J;Ng V;Patel SH;Placantonakis DG;Zagzag D;Golfinos J;Chi AS;Snuderl M
IDH突变型神经胶质瘤的生存率存在变异性，这取决于染色体事件。拷贝数变异（CNV）丰度与低级别和IDH突变型星形细胞瘤的生存相关。我们的目的是将IDH突变型星形细胞瘤中全基因组CNV丰度的程度与MRI特征相关联。回顾了18例WHO II-IV级IDH突变型星形细胞瘤的术前MRI和来自Illumina 850 k EPIC DNA甲基化阵列的CNV图。IDH突变型星形细胞瘤分为CNV稳定组（CNV-S）和CNV不稳定组（CNV-U），CNV稳定组具有</=3个染色体获得或丢失和缺乏局灶性基因扩增，CNV不稳定组具有>3个大染色体获得/丢失和/或局灶性扩增。评估MR特征、rCBV、CNV丰度和进展时间之间的相关性。使用DSC T2* 灌注分析获得肿瘤相对脑血容量估计值（rCBV）。有9例（50%）CNV-S和9例（50%）CNV-U IDH突变型星形细胞瘤。CNV-U肿瘤在FLAIR上显示出更大的平均肿瘤大小（P =.004）和最大直径（P = .004），并且还显示出比CNV-S肿瘤显著更高的中值rCBV（2.62 vs 0.78，P = .019）。CNV-U肿瘤倾向于具有较短的进展时间，尽管没有统计学显著性（P = .393）。CNV-U星形细胞瘤的体积/直径较大，rCBV较高，提示IDH突变型星形细胞瘤的侵袭性成像表型与不稳定和侵袭性基因型相关。
There is variability in survival within IDH-mutant gliomas determined by chromosomal events. Copy number variation (CNV) abundance associated with survival in low-grade and IDH mutant astrocytoma have been reported. Our purpose was to correlate the extent of genome-wide CNV abundance in IDH-mutant astrocytomas with MRI features. Presurgical MRI and CNV plots derived from Illumina 850k EPIC DNA methylation arrays of 18 cases of WHO grade II-IV IDH-mutant astrocytomas were reviewed. IDH-mutant astrocytomas were divided into CNV stable group (CNV-S) with </=3 chromosomal gains or losses and lack of focal gene amplifications and CNV unstable group (CNV-U) with >3 large chromosomal gains/losses and/or focal amplifications. The associations between MR features, rCBV, CNV abundance and time to progression were assessed. Tumor relative cerebral blood volume estimates (rCBV) were obtained using DSC T2* perfusion analysis. There were 9 (50%) CNV-S and 9 (50%) CNV-U IDH-mutant astrocytomas. CNV-U tumors showed larger mean tumor size (P = .004) and maximum diameter on FLAIR (P = .004), and also demonstrated significantly higher median rCBV than CNV-S tumors (2.62 vs 0.78, P = .019). CNV-U tumors tended to have shorter time to progression although without statistical significance (P = .393). Larger size/diameter and higher rCBV were seen associated CNV-U astrocytomas, suggesting a correlation of aggressive imaging phenotype with unstable and aggressive genotype in IDH-mutant astrocytomas.
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DOI：
10.1016/j.neurad.2014.02.006
发表时间：
2015-07
期刊：
Journal of neuroradiology = Journal de neuroradiologie
影响因子：
--
作者：
Nicolasjilwan M;Hu Y;Yan C;Meerzaman D;Holder CA;Gutman D;Jain R;Colen R;Rubin DL;Zinn PO;Hwang SN;Raghavan P;Hammoud DA;Scarpace LM;Mikkelsen T;Chen J;Gevaert O;Buetow K;Freymann J;Kirby J;Flanders AE;Wintermark M;TCGA Glioma Phenotype Research Group
通讯作者：
TCGA Glioma Phenotype Research Group
影响因子：
64.8
作者：
Capper D;Jones DTW;Sill M;Hovestadt V;Schrimpf D;Sturm D;Koelsche C;Sahm F;Chavez L;Reuss DE;Kratz A;Wefers AK;Huang K;Pajtler KW;Schweizer L;Stichel D;Olar A;Engel NW;Lindenberg K;Harter PN;Braczynski AK;Plate KH;Dohmen H;Garvalov BK;Coras R;Hölsken A;Hewer E;Bewerunge-Hudler M;Schick M;Fischer R;Beschorner R;Schittenhelm J;Staszewski O;Wani K;Varlet P;Pages M;Temming P;Lohmann D;Selt F;Witt H;Milde T;Witt O;Aronica E;Giangaspero F;Rushing E;Scheurlen W;Geisenberger C;Rodriguez FJ;Becker A;Preusser M;Haberler C;Bjerkvig R;Cryan J;Farrell M;Deckert M;Hench J;Frank S;Serrano J;Kannan K;Tsirigos A;Brück W;Hofer S;Brehmer S;Seiz-Rosenhagen M;Hänggi D;Hans V;Rozsnoki S;Hansford JR;Kohlhof P;Kristensen BW;Lechner M;Lopes B;Mawrin C;Ketter R;Kulozik A;Khatib Z;Heppner F;Koch A;Jouvet A;Keohane C;Mühleisen H;Mueller W;Pohl U;Prinz M;Benner A;Zapatka M;Gottardo NG;Driever PH;Kramm CM;Müller HL;Rutkowski S;von Hoff K;Frühwald MC;Gnekow A;Fleischhack G;Tippelt S;Calaminus G;Monoranu CM;Perry A;Jones C;Jacques TS;Radlwimmer B;Gessi M;Pietsch T;Schramm J;Schackert G;Westphal M;Reifenberger G;Wesseling P;Weller M;Collins VP;Blümcke I;Bendszus M;Debus J;Huang A;Jabado N;Northcott PA;Paulus W;Gajjar A;Robinson GW;Taylor MD;Jaunmuktane Z;Ryzhova M;Platten M;Unterberg A;Wick W;Karajannis MA;Mittelbronn M;Acker T;Hartmann C;Aldape K;Schüller U;Buslei R;Lichter P;Kool M;Herold-Mende C;Ellison DW;Hasselblatt M;Snuderl M;Brandner S;Korshunov A;von Deimling A;Pfister SM
通讯作者：
Pfister SM
DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
影响因子：
4.8
作者：
Jain, Rajan;Narang, Jayant;Rock, Jack P.
通讯作者：
Rock, Jack P.
影响因子：
3.9
作者：
Lee, Seunghyun;Choi, Seung Hong;Kim, Il Han
通讯作者：
Kim, Il Han