Femur: MR imaging-guided radio-frequency ablation in a porcine model-feasibility study.
Femur: MR imaging-guided radio-frequency ablation in a porcine model-feasibility study.
复制标题
股骨：猪模型可行性研究中的 MR 成像引导射频消融。
DOI：
10.1148/radiol.2252001500
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Lewin,JonathanS
中科院分区：
文献类型：
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作者：
Aschoff,AndrikJ;Merkle,ElmarM;Emancipator,StevenN;Petersilge,CherylA;Duerk,JeffreyL;Lewin,JonathanS
目的：探讨磁共振成像引导和监测射频消融骨的可行性。材料和方法：使用0.2T开放式磁共振成像仪对5只猪的7根股骨进行消融。在MR透视(快速稳态进动成像，FISP序列)下，将一根11号的骨髓针经皮插入股骨远端干骺端，在进一步的图像引导下将射频电极引入骨中。热消融10min(90°C±2[Mean±SD])。MR随访在消融后立即进行，并在术后7天和14天再次进行(使用对比剂增强的T1加权、T2加权和快速短反转时间反转-恢复或STIR序列)。第14天处死动物，取股骨切片，脱钙，染色。图像分析测量病灶直径和对比噪声比(CNR)，评估并发症。结果：所有动物均获得技术成功。垂直于电极的病灶直径为15.4 mm±2.7 mm。未发现明显的并发症。热性病变表现为低信号，边缘清晰，呈高信号。T2加权像对消融后即刻病变大小的预测准确率最高，误差最小(2.7 mm±1.3)。增强后的T1加权像在第14天显示出最高的准确度(1.0 mm±1.0)。结论：以MR成像为唯一成像方式的射频消融骨是可行的，并且可以监测消融情况。
PURPOSE:To determine the feasibility of magnetic resonance (MR) imaging–guided and –monitored radio-frequency (RF) ablation of bone.MATERIALS AND METHODS:Seven femurs were treated in five pigs with use of a 0.2-T open MR imager. An 11-gauge bone marrow needle was percutaneously inserted into the distal femur metaphysis with MR fluoroscopy (fast imaging with steady-state precession, or FISP, sequences) to introduce an RF electrode into the bone with further image guidance. Thermal ablation was performed for 10 minutes (90°C ± 2 [mean ± SD]). MR follow-up was performed immediately after ablation and again at 7 and 14 days after the procedure (with contrast material–enhanced T1-weighted, T2-weighted, and fast short inversion time inversion-recovery, or STIR, sequences). The animals were sacrificed at day 14. The femurs were sliced, decalcified, and stained. Image analysis was performed to measure lesion diameter and contrast-to-noise ratio (CNR) and to evaluate complications.RESULTS:Technical success was obtained in all animals. The lesion diameter perpendicular to the electrode was 15.4 mm ± 2.7. No significant complications were noted. The thermal lesions displayed low signal intensity with a sharp rim of high signal intensity. T2-weighted images demonstrated the highest CNR and the lowest error in predicting the lesion size immediately after ablation (2.7 mm ± 1.3). Contrast-enhanced T1-weighted images demonstrated the highest accuracy at day 14 (1.0 mm ± 1.0).CONCLUSION:RF ablation of bone with MR imaging as the sole imaging modality is feasible and allows monitoring of the ablation.© RSNA, 2002