Host-parasite coevolutionary conflict between Arabidopsis and downy mildew
Host-parasite coevolutionary conflict between Arabidopsis and downy mildew
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DOI：
10.1126/science.1104022
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发表时间：
2004-12-10
期刊：
影响因子：
56.9
通讯作者：
Beynon, JL
中科院分区：
文献类型：
--
作者：
Allen, RL;Bittner-Eddy, PD;Beynon, JL
植物经常受到一系列不同病原体的攻击，但缺乏身体适应性免疫系统。尽管如此，自然植物种群并不经常遭受破坏性疾病流行。阐明植物基因中检测病原体(抗性基因)的等位基因多样性是如何抵消寄主入侵所需的病原体基因(致病效应因子)结构变化的，这对于我们理解自然植物种群的动态至关重要。RPP13抗性基因是到目前为止在模式植物拟南芥中分析的最多态的基因。在这里，我们报道了无毒基因ATR13的克隆，它触发了RPP13介导的抗性，并且我们发现它也表现出极端水平的氨基酸多态。在这两个组分中都可以看到多样化选择的证据表明，寄主和病原体可能在这些基因座上陷入了共同进化的冲突，其中病原菌试图逃避寄主抗性的努力与寄主新检测能力的发展相匹配。
Plants are constantly exposed to attack by an array of diverse pathogens but lack a somatically adaptive immune system. In spite of this, natural plant populations do not often suffer destructive disease epidemics. Elucidating how allelic diversity within plant genes that function to detect pathogens (resistance genes) counteracts changing structures of pathogen genes required for host invasion (pathogenicity effectors) is critical to our understanding of the dynamics of natural plant populations. The RPP13 resistance gene is the most polymorphic gene analyzed to date in the model plant Arabidopsis thaliana. Here we report the cloning of the avirulence gene, ATR13, that triggers RPP13-mediated resistance, and we show that it too exhibits extreme levels of amino acid polymorphism. Evidence of diversifying selection visible in both components suggests that the host and pathogen may be locked in a coevolutionary conflict at these loci, where attempts to evade host resistance by the pathogen are matched by the development of new detection capabilities by the host.