The initial design and feasibility study of an affordable high-resolution 100-cm long PET
The initial design and feasibility study of an affordable high-resolution 100-cm long PET
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经济实惠的高分辨率 100 厘米长 PET 的初步设计和可行性研究
DOI：
10.1109/nssmic.2007.4437029
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Shitao Liu
中科院分区：
文献类型：
--
作者：
W. Wong;Yuxuan Zhang;Hongdi Li;H. Baghaei;R. Ramirez;Jiguo Liu;Shitao Liu
这是一个负担得起的高分辨率100 cm长的PET覆盖整个身体（EB-PET）的设计和可行性研究，用于在一个固定的床位置成像头部和躯干。我们的设计研究表明，EB-PET可以在2-4分钟内以低2.5 mCi FDG剂量对整个身体进行成像。高患者通量可以降低全身成像的成本，低剂量将允许更频繁的癌症管理监测。EB-PET可以同时捕获动态全身时间-活动图像和动脉（心脏）输入功能，以产生全身定量代谢图像，从而改善诊断并测量治疗的全身系统副作用。使用EB-PET的动态成像还可以将全身PET成像从当前PET所需的静态FDG类型的示踪剂解放为新类别的更动态的示踪剂。EB-PET探测系统基于我们实验室开发的最新一代低成本BGO探测器原型，每个PMT（直径39 mm）可以解码121个BGO晶体，从而使这个非常大的系统仅使用1768 PMT即可获得205，700个高分辨率晶体（3.5 x 3.5 x 20 mm）。还使用蒙特卡罗（MC）模拟（GATE/GEANT）计算了点源、NEMA内斯体模和全身Turkington体模的系统分辨率和内斯特性。原型探测器实现了15%的能量分辨率，并清晰地解码了3.5 x 3.5 mm探测器。利用这些数据，MC模拟表明，对于5个交叉环重合（274个交叉环重合），中心轴向图像分辨率为3.2 mm（4.4 mm），而在10 cm轴向半径处，图像分辨率为4.2 mm（5.1 mm）。
This is a design and feasibility study of an affordable high-resolution 100 cm long PET covering the entire body (EB-PET) for imaging head-&-torso in one fixed bed position. Our design studies show that EB-PET may image the entire body in 2-4 minutes with a low 2.5 mCi FDG dose. The high patient throughput may lower the cost of wholebody imaging and the low dose would allow more frequent cancer-management monitoring. EB-PET can capture dynamic wholebody time-activity images and arterial (cardiac) input function concurrently to yield quantitative metabolic images for the wholebody to improve diagnosis and to measure wholebody systemic side effects of therapy. Dynamic imaging using EB-PET may also unshackle wholebody PET imaging from the static FDG-type of tracers required by current PET to new classes of more dynamic tracers. The EB-PET detection system is based on the latest generation of the low-cost BGO detector prototypes developed in our laboratory which can decode 121 BGO crystals per PMT (39 mm diameter), thereby enabling this very large system to use only 1768 PMT for its 205,700 high resolution crystals (3.5 x 3.5 x 20 mm). The system resolution and NES characteristics were also calculated with Monte Carlo (MC) simulations (GATE/GEANT) for point sources, NEMA NES phantom and wholebody Turkington phantoms. Prototype detectors achieved a 15% energy resolution and clearly decoded 3.5 x 3.5 mm detectors. With such data, MC simulations show that the central transaxial image resolution is 3.2 mm (4.4 mm) for 5 cross-ring coincidences (274 cross-ring coincidences), while at 10 cm transaxial radius, the image resolution is 4.2 mm (5.1 mm).