The EEG, Evoked Potentials, and Single-unit Activity during Ketamine Anesthesia in Cats
The EEG, Evoked Potentials, and Single-unit Activity during Ketamine Anesthesia in Cats
复制标题
猫氯胺酮麻醉期间的脑电图、诱发电位和单单位活动
作者：
Y. Kayama;K. Iwama
研究了氯胺酮对允许自由活动或仅受最低限度限制的猫的影响。记录EEG、诱发电位和单位活动。静脉注射氯胺酮后不久，感觉运动和视觉皮层的低电压快波振幅增加，海马的持续θ波被去兴奋活动所取代。之后，新皮层和海马体的癫痫发作活动都以爆发的形式出现。氯胺酮显着增强的感觉运动和视觉皮层的诱发电位响应于电刺激内侧丘系和视交叉，分别。氯胺酮诱导的感觉运动皮层的EEG去极化与自发单一放电的增加有关。这些发现被解释为表明氯胺酮的作用是同时刺激新皮质、海马和其他皮质下核，最终诱导癫痫发作活动。这挑战了氯胺酮作为解离性麻醉剂的概念。
The effects of ketamine in cats which were allowed to move about freely or restrained only minimally were studied. EEC, evoked potentials, and single-unit activity were recorded. Soon after intravenous injection of ketamine, low-voltage fast waves of the sensorimotor and visual cortices increased in amplitude, and the on-going theta waves of the hippocampus were replaced by desynchronized activity. Later, the seizure activity in the neocortex, as well as that in the hippocampus, appeared as bursts. Ketamine markedly enhanced the evoked potentials of the sensorimotor and visual cortices in response to electrical stimulation of the medial lemniscus and optic chiasm, respectively. Ketamine-induced EEG desynchronization of the sensorimotor cortex was associated with an increase in spontaneous unitary discharges. These findings were interpreted as indicating that the effect of ketamine is to stimulate the neocortex, hippocampus, and other subcortical nuclei concurrently, eventually inducing seizure activity. This challenges the concept of ketamine as a dissociative anesthetic.