Estrogen receptor α and β expression in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women
Estrogen receptor α and β expression in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women
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DOI：
10.1016/s0015-0282(99)00113-2
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发表时间：
1999-06-01
影响因子：
6.7
通讯作者：
Yeh, O
中科院分区：
文献类型：
--
作者：
Chen, GD;Oliver, RH;Yeh, O
目的：评估绝经前和绝经后妇女阴道壁和子宫骶骨韧带中雌激素受体α和β的信使RNA（mRNA）的表达。设计：体外实验。设置：学术研究环境。患者：16名接受子宫切除术的连续观察的妇女。干预：在子宫切除术期间获得阴道前壁和子宫骶骨韧带的样本。主要结果测量：结果：雌激素受体α mRNA在阴道壁（16/16）和子宫骶韧带（16/16）中均有表达。雌激素受体β mRNA在绝经前妇女阴道壁组织中全部表达（12/12），绝经后妇女阴道壁组织中无表达（0/4）。结论：雌激素受体α和β在绝经前和绝经后妇女阴道壁和子宫骶骨韧带中均有表达，雌激素受体β mRNA在绝经后妇女子宫骶骨韧带中也有表达。雌激素受体β在绝经后妇女的阴道壁中缺失。（Fertil Steril（R）1999;71.1099-1102. (C)1999年由美国生殖医学学会出版。
Objective: To assess the expression of messenger RNA (mRNA) for estrogen receptors alpha and beta in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women.Design: In vitro experiment.Setting: Academic research environment.Patient(s): Sixteen consecutively seen women who underwent hysterectomy.Intervention(s): Samples of anterior vaginal walls and uterosacral ligaments were obtained during hysterectomy.Main Outcome Measure(s): Reverse transcriptase-polymerase chain reaction analysis for estrogen receptor mRNA.Result(s): Messenger RNA transcripts for estrogen receptor alpha were present in all samples of vaginal walls (16/16) and uterosacral ligaments (16/16). Estrogen receptor beta mRNA was detected in all samples of vaginal walls from premenopausal women (12/12) but in none of those from postmenopausal women (0/4). Estrogen receptor beta mRNA was found in most samples of uterosacral ligaments from premenopausal women (10/12) and in some of those from postmenopausal women (2/4).Conclusion(s): Estrogen receptors alpha and beta were expressed in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women. Estrogen receptor beta was absent from the vaginal walls of postmenopausal women. (Fertil Steril(R) 1999;71.1099-1102. (C) 1999 by American Society for Reproductive Medicine.).