Metamorphopsia Associated with Branch Retinal Vein Occlusion.
Metamorphopsia Associated with Branch Retinal Vein Occlusion.
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DOI：
10.1371/journal.pone.0153817
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Muraoka Y
中科院分区：
文献类型：
--
作者：
Manabe K;Tsujikawa A;Osaka R;Nakano Y;Fujita T;Shiragami C;Hirooka K;Uji A;Muraoka Y
应用M-CHARTS对急性视网膜分支静脉阻塞（BRVO）患者的视物变形进行定量测量，并阐明导致视物变形的病理形态学。这项前瞻性研究包括42例连续的急性BRVO患者（42只眼）。在基线和雷珠单抗治疗后1个月，用M-CHARTS测量视物变形，并用光学相干断层扫描仪检查视网膜形态学变化。基线时，29只（69.0%）眼在垂直和/或水平方向上检测到视物变形;平均垂直和水平评分分别为0.59 ± 0.57和0.52 ± 0.67。最大视网膜内层厚度与M-CHARTS评分无关，但M-CHARTS评分与中心凹总厚度（r = 0.43，p = 0.004）、浆液性视网膜脱离高度（r = 0.31，p = 0.047）和最大视网膜外层厚度（r = 0.36，p = 0.020）相关。治疗后1个月，内外视网膜厚度均显著降低。29只眼中有26只（89.7%）持续存在视物变形。治疗后M-CHARTS评分与任何治疗后形态学参数均不相关。然而，治疗后M-CHARTS评分与基线总中心凹厚度弱相关（r = 0.35）。与基线M-CHARTS评分密切相关（r = 0.78，p < 0.001）。使用M-CHARTS对与急性BRVO相关的视物变形进行定量。急性BRVO引起的外层视网膜的初始显微结构变化可能是导致视物变形的主要原因。
To apply M-CHARTS for quantitative measurements of metamorphopsia in eyes with acute branch retinal vein occlusion (BRVO) and to elucidate the pathomorphology that causes metamorphopsia. This prospective study consisted of 42 consecutive patients (42 eyes) with acute BRVO. Both at baseline and one month after treatment with ranibizumab, metamorphopsia was measured with M-CHARTS, and the retinal morphological changes were examined with optical coherence tomography. At baseline, metamorphopsia was detected in the vertical and/or horizontal directions in 29 (69.0%) eyes; the mean vertical and horizontal scores were 0.59 ± 0.57 and 0.52 ± 0.67, respectively. The maximum inner retinal thickness showed no association with the M-CHARTS score, but the M-CHARTS score was correlated with the total foveal thickness (r = 0.43, p = 0.004), the height of serous retinal detachment (r = 0.31, p = 0.047), and the maximum outer retinal thickness (r = 0.36, p = 0.020). One month after treatment, both the inner and outer retinal thickness substantially decreased. However, metamorphopsia persisted in 26 (89.7%) of 29 eyes. The posttreatment M-CHARTS score was not correlated with any posttreatment morphological parameters. However, the posttreatment M-CHARTS score was weakly correlated with the baseline total foveal thickness (r = 0.35. p = 0.024) and closely correlated with the baseline M-CHARTS score (r = 0.78, p < 0.001). Metamorphopsia associated with acute BRVO was quantified using M-CHARTS. Initial microstructural changes in the outer retina from acute BRVO may primarily account for the metamorphopsia.