Validity of self-reported smoking using urinary cotinine among vocational high school students.
Validity of self-reported smoking using urinary cotinine among vocational high school students.
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DOI：
10.3961/jpmph.2009.42.4.223
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发表时间：
2009-07-01
期刊：
影响因子：
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通讯作者：
Kim, Jong Yeon
中科院分区：
文献类型：
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作者：
Park, Soon Woo;Kim, Jong Yeon
目的：本研究旨在利用尿可替宁验证高中生自我报告的吸烟情况。方法：收集2007年11月两名职业高中生中130名男女学生的吸烟行为自我报告，并收集尿液样本进行可替宁分析。针对当前吸烟者、经常吸烟者和日常吸烟者的不同定义，使用STATA 9.0分析自我报告吸烟与尿可替宁之间的有效性和一致性。通过尿液 DRI 可替宁测定（Microgenics Corp.，Fremont，CA）在 Toshiba 200FR 上测量尿可替宁浓度。尿可替宁的临界点是50 ng/dl。结果：尿可替宁的浓度根据吸烟频率和吸烟量的不同而有显着差异。调查前1个月内至少吸烟1天的当前吸烟者的敏感性和特异性分别为90.9%和91.8%，Cohen kappa值为0.787。当前吸烟者（即主观吸烟者和每周吸烟者）的其他定义也显示出相当高的敏感性、特异性和卡帕值。结论：结果显示高中生自我报告吸烟的有效性很高。然而，由于样本量小和参与者的限制，将结果推广到全体高中生是谨慎的。
OBJECTIVES: This study was conducted to validate self-reported smoking among high school students using urinary cotinine.METHODS: A self report of smoking behavior was collected together with urine sample for cotinine analysis from 130 male and female students in two vocational high school students in November, 2007. Validity and agreement between self-reported smoking and urinary cotinine was analyzed with STATA 9.0 for different definitions of current smokers, and frequent and daily smokers. Urinary cotinine concentration was measured by the DRI Cotinine Assay for urine (Microgenics Corp., Fremont, CA) on Toshiba 200FR. The cut-off point of urinary cotinine was 50 ng/dl.RESULTS: The concentrations of urinary cotinine were significantly different according to the frequency and amount of smoking. Sensitivity and specificity was 90.9% and 91.8% respectively, and the Cohen's kappa value was 0.787 among the current smokers who smoked at least one day during one month preceding the survey. The comparable high sensitivity, specificity, and kappa value were shown also among the other definitions of current smokers, that is, subjective smokers, and weekly smokers.CONCLUSIONS: The results showed the high validity of self-reported smoking among high school students. However, due to the small sample size and limitation of the participants, it is cautious to generalize the results to overall high school students.