Primary ovarian fibrosarcoma with long-term survival: A report of two cases
Primary ovarian fibrosarcoma with long-term survival: A report of two cases
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DOI：
10.1111/j.1447-0756.2006.00448.x
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发表时间：
2006-10-01
影响因子：
1.6
通讯作者：
Lee, Jeong-Hee
中科院分区：
文献类型：
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作者：
Choi, Won-Jun;Ha, Man-Taek;Lee, Jeong-Hee
我们报告两例原发性卵巢纤维肉瘤检测两名妇女年龄分别为44岁和34岁。在第1例病例中，在左侧卵巢中检测到18 x 17 x 10 cm的多小叶肿瘤。在第二个病例中，在左侧和右侧卵巢分别发现了一个13 x 9 x 3 cm和一个7 x 6 x 2 cm的肿瘤。此外，检测到大量腹水。在这两种情况下，全子宫切除术，双侧附件切除术和网膜切除术进行。两例均未发现淋巴结肿大的证据。显微镜检查结果显示密集的细胞梭形肿瘤细胞，有丝分裂活性增加（分别为17和8/10高倍视野）。免疫组化分析显示肿瘤细胞波形蛋白阳性，平滑肌肌动蛋白、S-100和雌激素受体阴性。仅第2例患者的预后受体阳性。手术后，两名患者均接受了几个疗程的联合化疗。在10年和5年的随访期间，两名患者均未出现疾病复发的迹象。
We report on two cases of primary ovarian fibrosarcoma detected in two women aged 44 and 34 years old. In the first case, an 18 x 17 x 10 cm multilobular tumor was detected in the left ovary. In the second case, a 13 x 9 x 3 cm and a 7 x 6 x 2 cm tumor were found in the left and right ovaries, respectively. In addition, a large quantity of ascitic fluid was detected. In both cases, a total hysterectomy with bilateral adnexectomy and an omentectomy were performed. No evidence of lymph-node enlargement was detected in either case. Microscopic findings demonstrated densely, cellular spindle-shaped tumor cells with increased mitotic activity (17 and 8/10 high-power fields, respectively). Immunohistochemical analyses showed that tumor cells were positive for vimentin and negative for smooth muscle actin, S-100, and estrogen receptor. Progesterone receptor was positive only in the second case. After surgery, both patients received several courses of combination chemotherapy. Neither patient demonstrated any evidence of disease recurrence during follow-up for 10 years and 5 years, respectively.