The Pro12Ala polymorphism in PPARγ2 gene affects lipid parameters in Greek primary school children:: A case of gene-to-gender interaction
The Pro12Ala polymorphism in PPARγ2 gene affects lipid parameters in Greek primary school children:: A case of gene-to-gender interaction
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DOI：
10.1097/00000441-200701000-00002
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Zampelas, Antonis
中科院分区：
文献类型：
--
作者：
Dedoussis, George V. Z.;Theodoraki, Eirini V.;Zampelas, Antonis
背景在本研究中，我们试图评估PPAR-gamma 2 Pro 12 Ala多态性对小学生血脂水平的影响。方法：对81名男性和92名女性学龄儿童进行基因分型。生化，人体测量和生活方式变量进行了评估。结果：14.1%的女性和14.8%的男性为杂合子，其余为纯合子。PPAR-gamma 2基因与性别对血脂水平的影响存在显著的交互作用。特别地，与Pro/Ala个体相比，Pro/Pro女性表现出更高的总胆固醇值（194 +/-32对180 +/-28 mg/dL，P = 0.06）和甘油三酯值（94 +/-31对77 +/-11 mg/dL，P = 0.045）。基因-性别交互作用项具有高度显著性（P < 0.001）。06另一方面，Pro/Pro男性显示出更高的HDL胆固醇值（47 8 vs 43 9 mg/dL，P = 0. 001），总胆固醇/HDL比值降低（4.04 +/- 0.59 vs 4.45 +/- 0.61，P = 0.031），apoB值较低（59.8 ± 11.3 vs 66.8 ± 6.6 mg/dL，P = 0.007）和较低的apoB/apoA 1比值（0.41 ± 0.09 vs 0.48 ± 0.08，P = 0.019）。即使调整了体重指数（BMI）、总能量摄入、总脂肪摄入和饱和脂肪摄入后，总胆固醇/高密度脂蛋白（HDL）胆固醇和apoB/apoA 1比值的差异仍然显著。对于女性，在总胆固醇/HDL水平（基因-性别交互作用P = 0.001）和apoB/apoA 1水平（基因-性别交互作用P = 0.029）基因型之间未观察到差异。结论：我们首次显示了基因与性别的相互作用，总胆固醇/高密度脂蛋白和载脂蛋白B/载脂蛋白A1的比例，在男性学童基因分型的过氧化物酶体增殖物激活受体-γ 2蛋白12丙氨酸;载脂蛋白B/载脂蛋白A1。
Background. In the present study we sought to evaluate the impact of the PPAR-gamma 2 Pro12Ala polymorphism on blood lipid levels of primary school children. Methods: 81 male and 92 female schoolchildren were genotyped. Biochemical, anthropometric, and lifestyle variables were assessed. Results: 14.1% females and 14.8% males were heterozygotes, while the rest of the subjects were homozygotes for the Pro allele. A significant interaction between the PPAR-gamma 2 gene and gender on blood lipid levels was detected. in particular, Pro/Pro females exhibited higher values of total cholesterol (194 +/- 32 vs 180 +/- 28 mg/dL, P = 0.06) and triglycerides (94 +/- 31 vs 77 +/- 11 mg/dL, P = 0.045) compared to Pro/Ala individuals. The gene-to-gender interaction term was highly significant (P < 0.001). 06 the other hand, Pro/Pro males showed higher values of HDL cholesterol (47 8 vs 43 9 mg/dL, P = 0.001), lower total cholesterol/HDL ratio (4.04 +/- 0.59 vs 4.45 +/- 0.61, P = 0.031), lower values of apoB (59.8 +/- 11.3 vs 66.8 +/- 6.6 mg/dL, P = 0.007) and lower values of apoB/apoA1 ratio (0.41 +/- 0.09 vs 0.48 +/- 0.08, P = 0.019) compared with Pro/Ala. Even after adjusting for body mass index (BMI), total energy intake, total fat intake and saturated fat intake, differences in total cholesterol/high-clensity lipoprotein (HDL) cholesterol and the apoB/apoA1 ratios remained significant. Regarding females, no differences were observed among genotypes concerning total cholesterol/HDL levels (P for gene-to-gender interaction = 0.001) and the apoB/apoA1 levels (P for gene-to-gender interaction = 0.029). Conclusion: We show for the first time a gene-to-gender interaction on total cholesterol/HDL and apoB/apoA1 ratios, in male schoolchildren genotyped for PPAR - gamma 2 Pro12Ala; apoB/apoA1.