Wireless implantable chip with integrated nitinol-based pump for radio-controlled local drug delivery
Wireless implantable chip with integrated nitinol-based pump for radio-controlled local drug delivery
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DOI：
10.1039/c4lc01290a
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发表时间：
2015-01-01
期刊：
影响因子：
6.1
通讯作者：
Takahata, Kenichi
中科院分区：
文献类型：
--
作者：
Fong, Jeffrey;Xiao, Zhiming;Takahata, Kenichi
我们展示了一种嵌入微流体泵的主动、可植入药物输送装置，该微流体泵由无线电控制的致动器驱动，用于暂时药物输送。聚酰亚胺封装的10 x 10 x 2 mm（3）芯片包含一个微机械泵室和Parylene C止回阀，通过使用外部射频（RF）电磁场无线激活致动器，迫使药物从76 μ L储药器中释放。基于镍钛合金（一种生物相容性形状记忆合金）的矩形螺旋线圈驱动器被开发用于执行泵送操作中的类似弹簧的驱动。镍钛诺线圈致动器本身形成了一个被动的185 MHz谐振电路，该电路作为自热源，通过RF功率传输激活，以实现频率选择性致动和泵送。所制造的原型的实验无线操作示出了测试试剂从放置在液体中的装置的成功释放，并且通过具有1.1W的输出功率的辐射调谐RF场来激发。这些测试揭示了219 nL的单次释放体积，表明装置的容量类似于从其储库中进行350次单独的药物喷射。还详细报道了激活器件的热行为。这一概念验证原型验证了无线射频泵送在完全受控、持久的药物输送中的有效性，这是通过高度微型化的植入物实现患者量身定制、有针对性的局部药物输送的关键一步。
We demonstrate an active, implantable drug delivery device embedded with a microfluidic pump that is driven by a radio-controlled actuator for temporal drug delivery. The polyimide-packaged 10 x 10 x 2 mm(3) chip contains a micromachined pump chamber and check valves of Parylene C to force the release of the drug from a 76 mu L reservoir by wirelessly activating the actuator using external radio-frequency (RF) electromagnetic fields. The rectangular-shaped spiral-coil actuator based on nitinol, a biocompatible shape-memory alloy, is developed to perform cantilever-like actuation for pumping operation. The nitinol-coil actuator itself forms a passive 185 MHz resonant circuit that serves as a self-heat source activated via RF power transfer to enable frequency-selective actuation and pumping. Experimental wireless operation of fabricated prototypes shows successful release of test agents from the devices placed in liquid and excited by radiating tuned RF fields with an output power of 1.1 W. These tests reveal a single release volume of 219 nL, suggesting a device's capacity of similar to 350 individual ejections of drug from its reservoir. The thermal behavior of the activated device is also reported in detail. This proof-of-concept prototype validates the effectiveness of wireless RF pumping for fully controlled, long-lasting drug delivery, a key step towards enabling patient-tailored, targeted local drug delivery through highly miniaturized implants.