Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa
Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa
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DOI：
10.1016/j.jvoice.2010.10.006
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发表时间：
2012-01-01
期刊：
影响因子：
2.2
通讯作者：
Harabuchi, Yasuaki
中科院分区：
文献类型：
--
作者：
Sato, Kiminori;Umeno, Hirohito;Harabuchi, Yasuaki
目标。位于声带黏膜两端黄斑（maculae flavae, MFe）中的声带星状细胞（VFSCs）被推测参与细胞外基质的代谢。MFe也被认为是人声带粘膜生长发育的重要结构。由发声引起的张力（声带振动）被假设刺激VFSCs加速细胞外基质的产生。对出生后未发音的儿童声带粘膜进行组织学研究。研究设计。人儿童声带黏膜组织学分析。本文对2例7岁和12岁脑瘫患儿的声带粘膜进行了光镜和电镜观察，并与正常人进行了比较。声带黏膜和MFe发育不全，发育不全，没有声带韧带、赖因克间隙和层状结构。固有层呈均匀结构。MFe内部分VFSCs变性，胞质外周可见少量囊泡。VFSCs合成的纤维蛋白和糖胺聚糖等细胞外基质较少。VFSCs活性明显降低。出生后的声带振动（发声）是人声带粘膜生长发育的重要因素。
Objectives. Vocal fold stellate cells (VFSCs) in the maculae flavae (MFe) located at both ends of the vocal fold mucosa are inferred to be involved in the metabolism of extracellular matrices. MFe are also considered to be an important structure in the growth and development of the human vocal fold mucosa. Tension caused by phonation (vocal fold vibration) is hypothesized to stimulate VFSCs to accelerate production of extracellular matrices. Human child vocal fold mucosae unphonated since birth were investigated histologically.Study Design. Histologic analysis of human child vocal fold mucosa.Methods. Vocal fold mucosae, which have remained unphonated since birth, of two children (7 and 12 years old) with cerebral palsy were investigated by light and electron microscopy and compared with normal subjects.Results. Vocal fold mucosae and MFe were hypoplastic and rudimentary and did not have a vocal ligament, Reinke's space, or the layered structure. The lamina propria appeared as a uniform structure. Some VFSCs in the MFe showed degeneration and not many vesicles were present at the periphery of the cytoplasm. The VFSCs synthesized fewer extracellular matrices, such as fibrous protein and glycosaminoglycan. The VFSCs appeared to have decreased activity.Conclusion. Vocal fold vibration (phonation) after birth is an important factor in the growth and development of the human vocal fold mucosa.