The effect of systemic antibiotics on clinical and patient-reported outcome measures of oral implant therapy with simultaneous guided bone regeneration
The effect of systemic antibiotics on clinical and patient-reported outcome measures of oral implant therapy with simultaneous guided bone regeneration
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DOI：
10.1111/clr.13580
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发表时间：
2020-02-17
影响因子：
4.3
通讯作者：
Lang, Niklaus P.
中科院分区：
文献类型：
--
作者：
Payer, Michael;Tan, Wah Ching;Lang, Niklaus P.
目的探讨系统性抗生素对口腔种植同期引导骨再生(GBR)患者术后并发症的影响。材料与方法236例口腔种植患者在7个中心接受同期引导骨再生(GBR)。试验组在术前1h给予阿莫西林2g，术后1~3d每日3次，每次500 mg。对照组服用安慰剂。随机分组。主要结果变量为PROMS，记录为视觉模拟评分，在第1-7天和第14天评估疼痛、肿胀、血肿和出血。术后并发症作为次要结果变量在术后1、2、4和12周进行检测。结果两组胎膜早破评分差异无统计学意义(p>；0.05)。在手术后并发症方面也有同样的发现。4颗种植体丢失--3颗在试验组，1颗在对照组。结论在这项试验中，系统抗生素并没有为胎膜早破提供额外的好处，也没有预防内科和牙周健康的患者在接受口腔种植治疗的同时进行GBR手术后的并发症。然而，仍然需要更大样本量的进一步研究来支持这项研究的临床结果。
Objectives The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR).Materials and Methods A total of 236 medically and periodontally healthy patients received oral implants with simultaneous GBR at seven centres. Pre-operative antibiotics of 2 g amoxicillin were prescribed to the test group 1 hr prior to surgery and 500 mg thrice daily on days 1-3 after surgery. The control group was given a placebo. Group allocation was performed randomly. Primary outcome variables were PROMs recorded as visual analogue scale scores assessed on days 1-7 and 14 on pain, swelling, haematoma and bleeding. Post-operative complications as secondary outcome variables were examined at 1, 2, 4 and 12 weeks from surgery. Chi-square tests and repeated measures of analysis of variance (ANOVA) were performed for statistical evaluation.Results No statistically significant differences (p > .05) between the two groups were detected for the evaluated PROMs. The same was noted with respect to post-surgical complications. Four implants were lost-three in the test group and one in the control group.Conclusion In this trial, systemic antibiotics did not provide additional benefits to PROMs, nor the prevention of post-surgical complications in medically and periodontally healthy patients undergoing oral implant therapy with simultaneous GBR. However, further studies with larger sample sizes are still required to support the clinical outcomes of this study.