EVALUATION OF CIS-DIAMMINEDICHLOROPLATINUM (II) (CISPLATIN) NEUROTOXICITY IN RATS
EVALUATION OF CIS-DIAMMINEDICHLOROPLATINUM (II) (CISPLATIN) NEUROTOXICITY IN RATS
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DOI：
10.1016/0041-008x(87)90178-5
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发表时间：
1987-06-15
影响因子：
3.8
通讯作者：
GISPEN, WH
中科院分区：
文献类型：
--
作者：
DEKONING, P;NEIJT, JP;GISPEN, WH
采用电生理和功能试验研究了顺铂对大鼠的神经毒性。该药物每周腹腔注射2次（1mg /kg），累积剂量为19.0 mg/kg体重。在此剂量下，h反射相关感觉神经传导速度降低。停药后，h反射相关感觉神经传导速度缓慢改善。在整个中毒期间，运动神经传导速度未受影响，同心针检查未显示神经去支配的迹象。此外，对脚底局部有害刺激的感觉运动反应不受顺铂治疗的影响。由此可见，测量与h反射相关的感觉神经传导速度是评价顺铂对大鼠神经毒性的有效而准确的工具。
Cisplatin neurotoxicity was studied in rats by using electrophysiological and functional tests. The drug was injected intraperitoneally two times a week (1 mg/kg) up to a cumulative dose of 19.0 mg/kg body wt. At this dose the H-reflex-related sensory nerve comduction velocity was reduced. After cessation of drug administration, the H-reflex-related sensory nerve conduction velocity slowly improved. The motor nerve conduction velocity remained unaffected throughout the intoxication period and concentric needle investigation showed no signs of denervation. In addition, the sensorimotor response to a noxious stimulus presented locally to the foot sole was not affected by the cisplatin treatment. It is concluded that measurement of H-reflex-related sensory nerve conduction velocity is a useful and accurate tool in the evaluation of cisplatin neurotoxicity in rats.