Methamphetamine Fails to Alter the Noradrenergic Integrity of the Heart A Comparison with the Parkinsonism-Inducing Neurotoxin MPTP
Methamphetamine Fails to Alter the Noradrenergic Integrity of the Heart A Comparison with the Parkinsonism-Inducing Neurotoxin MPTP
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DOI：
10.1196/annals.1432.017
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Fornai, Francesco
中科院分区：
文献类型：
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作者：
Ruffoli, Riccardo;Soldani, Paola;Fornai, Francesco
长期使用甲基苯丙胺会导致心肌病和黑质纹状体多巴胺缺乏，这在一定程度上类似于帕金森病。本研究探讨了甲基苯丙胺和帕金森病诱导神经毒素1-甲基-4-苯基-1，2，3，6-四氢吡啶慢性给药后发生的心脏效应。尽管关于黑质纹状体多巴胺去神经支配的相似之处，甲基苯丙胺未能产生慢性去甲肾上腺素消耗在心脏中，从而与帕金森病或1-甲基-4-苯基-1，2，3，6-四氢吡啶给药后发生的情况形成对比。这些数据表明，甲基苯丙胺引起的慢性心血管效应依赖于生化变化，这些变化与1-甲基-4-苯基-1，2，3，6-四氢吡啶或帕金森病过程中激活的变化不同。
The chronic use of methamphetamine leads to cardiomyopathy and a nigrostriatal dopamine deficiency that partly mimics what occurs in Parkinson's disease. This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or during the course of Parkinson's disease.