Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ.
Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ.
复制标题
大鼠原位具有假定内在爆发特性的呼吸神经元的位置和特性。
DOI：
10.1113/jphysiol.2009.170308
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Paton,JulianFR
中科院分区：
文献类型：
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作者：
St-John,WalterM;Stornetta,RuthL;Guyenet,PatriceG;Paton,JulianFR
使用thein situatively动脉灌注制剂的新生大鼠和幼年大鼠，我们提供了第一个描述的位置，形态和递质含量的人口的呼吸神经元，保留爆破行为后，离子型受体阻滞剂。所有爆发神经元在正常呼吸时均表现出吸气放电。这些神经元主要是腹侧能神经元，位于腹侧呼吸柱的一个区域内，该区域包括前Bötzinger复合体和位于尾部的腹侧呼吸群。猝发行为是电压和持续钠电流依赖性的，并且可以被氰化钠刺激以激活这种持续钠电流。爆发神经元的数量可能与先前在体外新生儿切片中描述的重叠。根据目前和以前的研究结果，我们假设，这种爆发式放电可能会释放时，大脑受到严重缺氧或缺血，这种爆发式放电可能是喘息的基础。
Using thein situarterially perfused preparations of both neonatal and juvenile rats, we provide the first description of the location, morphology and transmitter content of a population of respiratory neurones that retains a bursting behaviour after ionotropic receptor blockade. All burster neurones exhibited an inspiratory discharge during eupnoeic respiration. These neurones were predominantly glutamatergic, and were located within a region of the ventral respiratory column that encompasses the pre‐Bötzinger complex and the more caudally located ventral respiratory group. Bursting behaviour was both voltage and persistent sodium current dependent and could be stimulated by sodium cyanide to activate this persistent sodium current. The population of burster neurones may overlap with that previously described in the neonatal slicein vitro. Based upon the present and previous findings, we hypothesize that this burster discharge may be released when the brain is subject to severe hypoxia or ischaemia, and that this burster discharge could underlie gasping.