Coagulation factor levels in non-metastatic colorectal cancer patients
Coagulation factor levels in non-metastatic colorectal cancer patients
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DOI：
10.1177/172460080802300106
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Vittoria, A.
中科院分区：
文献类型：
--
作者：
Battistelli, S.;Stefanoni, M.;Vittoria, A.
有证据表明，高水平的血浆因子（F）VIII、FIX、FXI和纤维蛋白原是静脉血栓栓塞症的独立危险因素。目的：测定一组非转移性结直肠癌患者血浆中几种凝血因子和C4b结合蛋白（C4BP）的浓度，以探讨癌症获得性血栓形成倾向的某些方面。在73例非转移性结直肠癌患者（48例结肠癌和25例直肠癌）和67例匹配的对照受试者中测定了血浆纤维蛋白原、Fill、FV、FVII、FVIII、FIX、FX、FXI和FXII活性水平和C4BP浓度。没有人在任何一组有以前的血栓events.Results：平均血浆浓度的纤维蛋白原（功能和抗原），FVIII，FIX，FV和C4BP显着高于结直肠癌患者比对照组，而FVII和FXII水平显着下降。在凝血因子增加和C4BP浓度之间发现了几种相关性，而FVII与FXII高度相关。在结直肠癌患者中，高血浆纤维蛋白原、FVIII和FIX水平可能代表术后即刻静脉血栓形成并发症的进一步危险因素，而降低的FVII和FXII浓度可能是血管内凝血激活的指标，仍处于亚临床阶段。
There is evidence that high plasma levels of factor (F) VIII, FIX, FXI and fibrinogen are independent risk factors for venous thromboembolism.Aim: To determine the plasma concentrations of several coagulation factors and C4b-binding protein (C4BP) in a group of patients with non-metastatic colorectal cancer in order to investigate some aspects of cancer-acquired thrombophilia.Methods: Plasma fibrinogen, Fill, FV, FVII, FVIII, FIX, FX, FXI and FXII activity levels and C4BP concentrations were determined in 73 patients with non-metastatic colorectal cancer (48 colon and 25 rectum) and in 67 matched control subjects. No one in either group had had previous thrombotic events.Results: Mean plasma concentrations of fibrinogen (functional and antigen), FVIII, FIX, FV and C4BP were significantly higher in colorectal cancer patients than in control subjects, while FVII and FXII levels were significantly decreased. Several correlations were found between the increased coagulation factors and C4BP concentrations, while FVII was highly correlated with FXII.Conclusions: in colorectal cancer patients high plasma fibrinogen, FVIII and FIX levels might represent further risk factors for venous thrombotic complications in the immediate post-surgery period, while decreased FVII and FXII concentrations may be an index of intravascular coagulation activation, still in a subclinical phase.