Endogenous sex hormones and the risk of prostate cancer: A prospective study
Endogenous sex hormones and the risk of prostate cancer: A prospective study
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DOI：
10.1002/ijc.23326
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发表时间：
2008-05-15
影响因子：
6.4
通讯作者：
Hayes, Richard B.
中科院分区：
文献类型：
--
作者：
Weiss, Jocelyn M.;Huang, Wen-Yi;Hayes, Richard B.
性类固醇激素通过其在前列腺细胞增殖、分化和凋亡中的作用影响前列腺的发育和维持。虽然被怀疑参与前列腺癌的发生，但在流行病学研究中尚未明确确定循环雄激素与前列腺癌之间的关联。我们对前列腺、肺、结直肠和卵巢（PLCO）癌症筛查试验中前瞻性收集的样本进行了一项巢式病例对照研究，以检查前列腺癌与雄烯二酮（Delta 4-A）、睾酮（T）、性激素结合球蛋白（SHBG）和3 α-雄甾烷葡糖苷酸（3a-diolG）的相关性。共选择727例高加索人前列腺癌病例（年龄≥ 65岁，N = 396）和889例匹配对照进行分析。总体而言，前列腺癌的风险与血清T、估计的游离和生物可利用T以及SHBG无关;然而，风险随着T：SHBG比值的增加而增加（P趋势= 0.01），主要与老年男性（≥ 65岁，P趋势= 0.001）的风险有关，特别是侵袭性疾病[最高与最低四分位数：比值比（OR）2.76，95%置信区间（CI）1.50-5.091]。未观察到Delta 4-A和3 α-diolG的明显模式。总之，我们的大型前瞻性研究没有显示血清性激素和前列腺癌之间关系的令人信服的证据。T：SHBG比率与老年男性人群的风险有关，但该比率在类固醇生物学中的意义尚不清楚。(C)2008 Wiley-Liss，Inc.
Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in epidemiologic studies. We conducted a nested case-control study with prospectively collected samples in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, to examine associations of prostate cancer with androstenedione (Delta 4-A), testosterone (T), sex hormone-binding globulin (SHBG) and 3 alpha-androstanediol glucuronide (3a-diolG). A total of 727 incident Caucasian prostate cancer cases (age >= 65 years, N = 396) and 889 matched controls were selected for this analysis. Overall, prostate cancer risks were unrelated to serum T, estimated free and bioavailable T, and SHBG; however, risks increased with increasing T:SHBG ratio (P-trend = 0.01), mostly related to risk in older men (>= 65 years, Ptrend = 0.001), particularly for aggressive disease [highest versus lowest quartile: odds ratio (OR) 2.76, 95% confidence interval (CI) 1.50-5.091. No clear patterns were noted for Delta 4-A and 3 alpha-diolG. In summary, our large prospective study did not show convincing evidence of a relationship between serum sex hormones and prostate cancer. T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (C) 2008 Wiley-Liss, Inc.