Hyperglycemia and Inflammatory Property of Circulating Monocytes are Associated with Inflammatory Property of Carotid Plaques in Patients Undergoing Carotid Endarterectomy
Hyperglycemia and Inflammatory Property of Circulating Monocytes are Associated with Inflammatory Property of Carotid Plaques in Patients Undergoing Carotid Endarterectomy
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DOI：
10.5551/jat.32680
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发表时间：
2016-01-01
影响因子：
4.4
通讯作者：
Satoh-Asahara, Noriko
中科院分区：
文献类型：
--
作者：
Tanaka, Masashi;Masuda, Shinya;Satoh-Asahara, Noriko
目的：本研究旨在确定接受颈动脉内膜切除术的患者中葡萄糖代谢与循环单核细胞或颈动脉斑块的促炎/抗炎特性之间的关系。方法：检查了 12 名糖尿病患者和 12 名非糖尿病患者的临床特征和循环单核细胞/颈动脉斑块中促炎/抗炎标记物的表达水平。结果：与非糖尿病患者相比，糖尿病患者的循环单核细胞显示出较高的肿瘤坏死因子 (TNF)-α 和较低的白细胞介素 (IL)-10 表达水平，这在糖尿病患者的颈动脉斑块中也观察到。高血糖分别与颈动脉斑块中IL-6(+)和IL-10(+)细胞的比例呈正相关和负相关。此外，我们确定循环单核细胞和颈动脉斑块之间的TNF-a和IL-6表达呈正相关。结论：循环单核细胞的炎症特性与颈动脉斑块的炎症特性相关。高血糖增加了颈动脉斑块的炎症特性并降低了抗炎特性。
Aim: This study aims to determine the association between glucose metabolism and proinflammatory/anti-inflammatory properties of circulating monocytes or those of carotid plaques in patients who underwent carotid endarterectomy.Methods: Clinical characteristics and expression levels of proinflammatory/anti-inflammatory markers in circulating monocytes/carotid plaques were examined in 12 patients with diabetes and 12 patients without diabetes. Results: Circulating monocytes from patients with diabetes revealed higher tumor necrosis factor (TNF)-alpha and lower interleukin (IL)-10 expression levels compared with those from patients without diabetes, which was also observed in carotid plaques from patients with diabetes. Hyperglycemia revealed positive and negative correlations with the ratios of IL-6(+) and IL-10(+) cells in carotid plaques, respectively. Moreover, we determined a positive correlation between circulating monocytes and carotid plaques with respect to TNF-a and IL-6 expressions.Conclusions: The inflammatory property of circulating monocytes was associated with that of carotid plaques. Hyperglycemia increased inflammatory properties and decreased anti-inflammatory properties of carotid plaques.