Cohesin and CTCF: cooperating to control chromosome conformation?
Cohesin and CTCF: cooperating to control chromosome conformation?
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DOI：
10.1002/bies.20787
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发表时间：
2008-08-01
期刊：
影响因子：
4
通讯作者：
Dorsett, Dale
中科院分区：
文献类型：
--
作者：
Gause, Maria;Schaaf, Cheri A.;Dorsett, Dale
凝聚素复合体最为人所知的是它在姐妹染色单体凝聚中的作用。在过去的几年里，它已成为明显的，凝聚素也调节基因表达，但它这样做的机制是未知的。最近，三个小组绘制了哺乳动物染色体中的许多粘附素结合位点，并发现与CCCTC结合因子（CTCF）有大量重叠。（（1-3））CTCF是一种绝缘子蛋白，可以阻断增强子-启动子相互作用，研究人员发现粘附素也有助于这种活性。因此，这些研究表明，至少有一种机制，通过这种机制，黏结蛋白可以控制基因表达。
The cohesin complex is best known for its role in sister chromatid cohesion. Over the past few years, it has become apparent that cohesin also regulates gene expression, but the mechanisms by which it does so are unknown. Recently, three groups mapped numerous cohesin-binding sites in mammalian chromosomes and found substantial overlap with the CCCTC-binding factor (CTCF).((1-3)) CTCF is an insulator protein that blocks enhancer-promoter interactions, and the investigators found that cohesin also contributes to this activity. Thus, these studies demonstrate at least one mechanism by which cohesin can control gene expression.