Current approaches to enhance CNS delivery of drugs across the brain barriers.
Current approaches to enhance CNS delivery of drugs across the brain barriers.
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目前增强中枢神经系统药物跨脑屏障输送的方法
DOI：
10.2147/ijn.s61288
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发表时间：
2014
影响因子：
8
通讯作者：
Tian XQ
中科院分区：
文献类型：
--
作者：
Lu CT;Zhao YZ;Wong HL;Cai J;Peng L;Tian XQ
虽然许多药物对中枢神经系统（CNS）疾病具有治疗潜力，但由于脑屏障的存在，这些药物很少用于临床。作为中枢神经系统的保护屏障，血脑屏障和血脑脊液屏障维持脑微环境、神经元活动和中枢神经系统的正常功能。已经研究了有效的CNS递送的不同策略。本文综述了目前的方法，以打开或促进穿透这些障碍，增强药物输送到中枢神经系统。这些方法概括为三大类：非侵入性，侵入性和杂项技术。本文综述了这些方法的研究进展，并对相关的机理和存在的问题进行了讨论。
Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed.