EFFECTS OF VIGABATRIN (GAMMA-VINYL GABA) ON NEUROTRANSMISSION-RELATED AMINO-ACIDS AND ON GABA AND BENZODIAZEPINE RECEPTOR-BINDING IN RATS
EFFECTS OF VIGABATRIN (GAMMA-VINYL GABA) ON NEUROTRANSMISSION-RELATED AMINO-ACIDS AND ON GABA AND BENZODIAZEPINE RECEPTOR-BINDING IN RATS
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DOI：
10.1111/j.1528-1157.1991.tb05251.x
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发表时间：
1991-03-01
期刊：
影响因子：
5.6
通讯作者：
RIEKKINEN, PJ
中科院分区：
文献类型：
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作者：
HALONEN, T;PITKANEN, A;RIEKKINEN, PJ
腹膜腔内注射12天的效果本文研究了大鼠给药后不同脑区(皮质、海马、小脑和脊髓)、脑脊液(CSF)和血液中神经递质相关氨基酸的变化。结果表明，GVG可增加大脑皮质和皮质下区域及脑脊液中GABA的水平，但不影响皮质中的GABA和苯二氮卓类受体。此外，海马区谷氨酸浓度以及皮质、海马区和小脑中天冬氨酸和谷氨酰胺浓度均呈剂量依赖性下降。脑内氨基酸水平的变化，除GABA外，并未反映在脑脊液中，但脑内不同区域的氨基酸水平与血清或脑脊液中的氨基酸水平没有显示出任何相关性。结果提示，GVG不仅可通过提高抑制性氨基酸GABA的水平，还可降低脑内兴奋性氨基酸的水平，从而抑制癫痫的发生和蔓延。
The effect of 12-day intraperitoneal i.p. administration of vigabatrin (GVG, gamma-vinyl GABA) to rats on the neurotransmission-related amino acids in various brain regions (cortex, hippocampus, cerebellum, and spinal cord), cisternal fluid (CSF) and blood was studied. Results showed that GVG administration increased the levels of GABA in cortical and subcortical regions of the brain and CSF without affecting GABA and benzodiazepine receptors in the cortex. In addition, a dose-dependent decrease was noted in the concentration of glutamate in the hippocampus and in the concentrations of aspartate and glutamine in the cortex, hippocampus, and cerebellum. The changes in the levels of amino acids in the brain, except for that of GABA, were not reflected in the CSF, however, and the levels of amino acids in discrete brain regions did not show any correlation with those in the serum or in the CSF. The results suggest that GVG administration might suppress development and spread of seizures not only by elevating the level of the inhibitory amino acid GABA, but also by decreasing the levels of excitatory amino acids in the brain.