Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls.
Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls.
复制标题
DOI：
10.1016/j.dadm.2017.10.005
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Bouwman FH
中科院分区：
文献类型：
--
作者：
den Haan J;Janssen SF;van de Kreeke JA;Scheltens P;Verbraak FD;Bouwman FH
视网膜可以反映阿尔茨海默病 (AD) 的神经病理学变化，并且可以通过光学相干断层扫描 (OCT) 轻松可视化。然而，视网膜厚度减少与 AD 相关，但没有淀粉样蛋白状态的信息。我们将淀粉样蛋白阳性早发性 AD (EOAD) 患者和淀粉样蛋白阴性对照的视网膜（层）厚度与 AD 生物标志物相关联。我们使用 OCT 测量了 15 名 EOAD 患者和 15 名对照者的黄斑厚度和视乳头周围视网膜神经纤维层厚度，并将视网膜厚度与磁共振成像萎缩的视觉评分相关联。两组中黄斑总厚度与顶叶皮质萎缩相关（Spearman ρ -0.603，P = .001）。与对照组相比，EOAD 组黄斑和视乳头周围视网膜神经纤维层厚度没有显着降低。视网膜厚度并不能区分 EOAD 和对照组，但与两组的顶叶皮质萎缩相关。这些发现可能表明大脑皮质变化在视网膜中的反映，与淀粉样蛋白无关。淀粉样蛋白阳性的早发性阿尔茨海默病患者和淀粉样蛋白阴性对照的视网膜厚度与顶叶皮质萎缩相关。黄斑和视网膜神经纤维层厚度不能区分淀粉样蛋白阳性的早发性 AD 患者和淀粉样蛋白阴性对照。大脑皮质变化的反映可能存在于视网膜中，与淀粉样蛋白无关。
The retina may reflect Alzheimer's disease (AD) neuropathological changes and is easily visualized with optical coherence tomography (OCT). Retinal thickness decrease has been correlated to AD, however, without information on amyloid status. We correlated retinal (layer) thickness to AD biomarkers in amyloid-positive early-onset AD (EOAD) patients and amyloid-negative controls. We measured macular thickness and peripapillary retinal nerve fiber layer thickness with OCT in 15 EOAD patients and 15 controls and correlated retinal thickness to visual rating scores for atrophy on magnetic resonance imaging. Total macular thickness correlated to parietal cortical atrophy in both groups (Spearman ρ −0.603, P = .001). Macular and peripapillary retinal nerve fiber layer thicknesses were not significantly decreased in EOAD compared to controls. Retinal thickness does not discriminate EOAD from controls but is correlated to parietal cortical atrophy in both groups. These findings may suggest reflection of cerebral cortical changes in the retina, independent of amyloid. Retinal thickness correlates with parietal cortical atrophy in amyloid-positive early-onset Alzheimer's disease patients and amyloid-negative controls. Macular and retinal nerve fiber layer thicknesses do not discriminate amyloid-positive early-onset AD patients from amyloid-negative controls. Reflection of cerebral cortical changes may be present in the retina, independent of amyloid.