Bats are natural reservoirs of SARS-like coronaviruses
Bats are natural reservoirs of SARS-like coronaviruses
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DOI：
10.1126/science.1118391
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发表时间：
2005-10-28
期刊：
影响因子：
56.9
通讯作者：
Wang, LF
中科院分区：
文献类型：
--
作者：
Li, WD;Shi, ZL;Wang, LF
2002年至2003年，中国南部地区出现严重急性呼吸综合征。其病原体SARS冠状病毒(SARS-CoV)的来源仍然不清楚。我们在这里报道，蝙蝠是冠状病毒的自然宿主，与导致SARS爆发的冠状病毒密切相关。这些病毒被称为类SARS冠状病毒(SL-CoV)，表现出比从人或果子狸身上分离的SARS-CoV更大的基因变异。SARS-CoV的人类分离株和果子狸分离株在系统发育上属于SL-CoV，表明导致SARS暴发的病毒是该冠状病毒组的成员。
Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS, outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak Was a member of this coronavirus group.