Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro.
Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro.
复制标题
甲状旁腺激素：3-34 片段体内和体外的影响。
DOI：
10.1126/science.6849118
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发表时间：
1983
期刊：
影响因子：
56.9
通讯作者：
M. Rosenblatt
中科院分区：
文献类型：
--
作者：
J. Mcgowan;T. Chen;J. Fragola;J. Puschett;M. Rosenblatt
将甲状旁腺激素的生物活性片段（由残基1-34组成）和它的体外拮抗剂片段3-34分别或联合给予慢性甲状旁腺切除的狗。这些片段也进行了研究，在体外与狗肾皮质膜。片段3-34在体外抑制片段1-34对腺苷酸环化酶的刺激，但在体内对肾磷酸盐转运无激动或拮抗作用。
The biologically active fragment ofparathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.